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    Zfyve16 zinc finger FYVE-type containing 16 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 499508, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Zfyve16provided by RGD
    Official Full Name
    zinc finger FYVE-type containing 16provided by RGD
    Primary source
    RGD:1564784
    See related
    EnsemblRapid:ENSRNOG00000013055 AllianceGenome:RGD:1564784
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1564784
    Summary
    Predicted to enable 1-phosphatidylinositol binding activity and phosphatidylinositol-3,4,5-trisphosphate binding activity. Predicted to be involved in endosomal transport and protein targeting to lysosome. Predicted to be located in cytosol and early endosome. Predicted to be active in early endosome membrane. Orthologous to human ZFYVE16 (zinc finger FYVE-type containing 16). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 104.2), Kidney (RPKM 101.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Zfyve16 in Genome Data Viewer
    Location:
    2q12
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (25448264..25495180, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (23713018..23757576, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (22060879..22105822, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene ankyrin repeat domain 34B Neighboring gene family with sequence similarity 151, member B Neighboring gene spermatogenic leucine zipper 1 Neighboring gene heterogeneous nuclear ribonucleoprotein K, pseudogene 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Endofin, an endosomal FYVE domain protein. Seet LF, et al. J Biol Chem, 2001 Nov 9. PMID 11546807
    2. SNX3 regulates endosomal function through its PX-domain-mediated interaction with PtdIns(3)P. Xu Y, et al. Nat Cell Biol, 2001 Jul. PMID 11433298
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 1-phosphatidylinositol binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylinositol-3,4,5-trisphosphate binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in endosomal transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endosomal transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein targeting to lysosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein targeting to lysosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in early endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in early endosome membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger FYVE domain-containing protein 16
    Names
    zinc finger, FYVE domain containing 16

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001191958.1 → NP_001178887.1  zinc finger FYVE domain-containing protein 16

      See identical proteins and their annotated locations for NP_001178887.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/TrEMBL
      D4ADF6
      Related
      ENSRNOP00000017705.6, ENSRNOT00000017705.8
      Conserved Domains (2) summary
      cd15729
      Location:745 → 811
      FYVE_endofin; FYVE domain found in endofin and similar proteins
      pfam11979
      Location:1174 → 1522
      DUF3480; Domain of unknown function (DUF3480)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      25448264..25495180 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006231783.5 → XP_006231845.1  zinc finger FYVE domain-containing protein 16 isoform X1

      See identical proteins and their annotated locations for XP_006231845.1

      UniProtKB/TrEMBL
      D4ADF6
      Conserved Domains (2) summary
      cd15729
      Location:745 → 811
      FYVE_endofin; FYVE domain found in endofin and similar proteins
      pfam11979
      Location:1174 → 1522
      DUF3480; Domain of unknown function (DUF3480)

    2. XM_006231784.4 → XP_006231846.1  zinc finger FYVE domain-containing protein 16 isoform X1

      See identical proteins and their annotated locations for XP_006231846.1

      UniProtKB/TrEMBL
      D4ADF6
      Conserved Domains (2) summary
      cd15729
      Location:745 → 811
      FYVE_endofin; FYVE domain found in endofin and similar proteins
      pfam11979
      Location:1174 → 1522
      DUF3480; Domain of unknown function (DUF3480)

    3. XM_039102826.2 → XP_038958754.1  zinc finger FYVE domain-containing protein 16 isoform X4

      UniProtKB/TrEMBL
      A6I4R2
      Conserved Domains (1) summary
      pfam11979
      Location:355 → 703
      DUF3480; Domain of unknown function (DUF3480)

    4. XM_063282343.1 → XP_063138413.1  zinc finger FYVE domain-containing protein 16 isoform X2

    5. XM_039102825.2 → XP_038958753.1  zinc finger FYVE domain-containing protein 16 isoform X3

      Conserved Domains (1) summary
      cd15729
      Location:745 → 811
      FYVE_endofin; FYVE domain found in endofin and similar proteins
    Nucleotide Protein Strain
    Heading Accession and Version

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