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    Fam220a family with sequence similarity 220, member A [ Rattus norvegicus (Norway rat) ]

    Gene ID: 498145, updated on 9-Dec-2024

    Summary

    Official Symbol
    Fam220aprovided by RGD
    Official Full Name
    family with sequence similarity 220, member Aprovided by RGD
    Primary source
    RGD:1561923
    See related
    EnsemblRapid:ENSRNOG00000024605 AllianceGenome:RGD:1561923
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Sipar
    Summary
    Predicted to enable STAT family protein binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to act upstream of or within protein dephosphorylation. Predicted to be located in acrosomal vesicle. Predicted to be active in nucleus. Orthologous to several human genes including FAM220A (family with sequence similarity 220 member A). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 265.9), Muscle (RPKM 170.8) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Fam220a in Genome Data Viewer
    Location:
    12p11
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (16111593..16127584, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (10997969..11013962, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (13043038..13067043, complement)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene collagen alpha-1(I) chain-like Neighboring gene ubiquitin specific peptidase 42 Neighboring gene cytohesin 3 Neighboring gene small integral membrane protein 10 like 3 Neighboring gene Rac family small GTPase 1 Neighboring gene diacylglycerol lipase, beta

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables STAT family protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables STAT family protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in acrosomal vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in acrosomal vesicle ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    protein FAM220A
    Names
    STAT3-interacting protein as a repressor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001017485.2NP_001017485.1  protein FAM220A

      See identical proteins and their annotated locations for NP_001017485.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000012
      UniProtKB/Swiss-Prot
      Q6DGF6
      UniProtKB/TrEMBL
      A6K1K4
      Related
      ENSRNOP00000108143.1, ENSRNOT00000143742.1
      Conserved Domains (1) summary
      pfam15487
      Location:2256
      FAM220; FAM220 family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      16111593..16127584 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)