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    fam83d family with sequence similarity 83 member D [ Danio rerio (zebrafish) ]

    Gene ID: 492689, updated on 9-Dec-2024

    Summary

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    Official Symbol
    fam83dprovided by ZNC
    Official Full Name
    family with sequence similarity 83 member Dprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-041111-264
    See related
    Ensembl:ENSDARG00000077883 AllianceGenome:ZFIN:ZDB-GENE-041111-264
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    im:7149534; zgc:162965
    Summary
    Predicted to enable protein kinase binding activity. Predicted to be involved in several processes, including positive regulation of cell cycle G1/S phase transition; protein localization to mitotic spindle; and regulation of intracellular signal transduction. Predicted to act upstream of or within cell division. Predicted to be located in cytoplasm. Predicted to be active in cytosol and mitotic spindle pole. Is expressed in proliferative region. Orthologous to human FAM83D (family with sequence similarity 83 member D). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See fam83d in Genome Data Viewer
    Location:
    chromosome: 11
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 11 NC_007122.7 (25328201..25336918)
    105 previous assembly GRCz10 (GCF_000002035.5) 11 NC_007122.6 (25090498..25099305)

    Chromosome 11 - NC_007122.7Genomic Context describing neighboring genes Neighboring gene DNA topoisomerase Ia Neighboring gene zinc fingers and homeoboxes 3a Neighboring gene uncharacterized LOC101882529 Neighboring gene si:dkeyp-97e7.9 Neighboring gene v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog Bb

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Evolution and genomic organization of muscle microRNAs in fish genomes. Nachtigall PG, et al. BMC Evol Biol, 2014 Sep 25. PMID 25253178, Free PMC Article
    2. Hematopoietic gene expression profile in zebrafish kidney marrow. Song HD, et al. Proc Natl Acad Sci U S A, 2004 Nov 16. PMID 15520368, Free PMC Article
    3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables protein kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell population proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in metaphase chromosome alignment ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of cell cycle G1/S phase transition IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein localization to mitotic spindle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of ERK1 and ERK2 cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of ERK1 and ERK2 cascade ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of TOR signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in mitotic spindle pole IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitotic spindle pole ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    protein FAM83D

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001089355.1 → NP_001082824.1  protein FAM83D

      See identical proteins and their annotated locations for NP_001082824.1

      Status: PROVISIONAL

      Source sequence(s)
      BC139679
      UniProtKB/Swiss-Prot
      A4QP72
      Related
      ENSDARP00000100036.2, ENSDART00000112209.3
      Conserved Domains (2) summary
      cd09184
      Location:21 → 291
      PLDc_FAM83D_N; N-terminal phospholipase D-like domain of the protein, Family with sequence similarity 83D
      pfam13091
      Location:150 → 284
      PLDc_2; PLD-like domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007122.7 Reference GRCz11 Primary Assembly

      Range
      25328201..25336918
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068224159.1 → XP_068080260.1  protein FAM83D isoform X2

    2. XM_068224158.1 → XP_068080259.1  protein FAM83D isoform X1

    3. XM_068224160.1 → XP_068080261.1  protein FAM83D isoform X3

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A4QP72.1 GenPept UniProtKB/Swiss-Prot:A4QP72

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.