wdfy2 WD repeat and FYVE domain containing 2 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: wdfy2provided by ZNC
Official Full Name: WD repeat and FYVE domain containing 2provided by ZNC
Primary source: ZFIN:ZDB-GENE-041111-211
See related: Ensembl:ENSDARG00000040453 AllianceGenome:ZFIN:ZDB-GENE-041111-211
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: sb:eu585; im:7144335; zgc:109708
Summary: Predicted to enable metal ion binding activity. Predicted to be involved in positive regulation of fat cell differentiation. Predicted to be active in early endosome. Orthologous to human WDFY2 (WD repeat and FYVE domain containing 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 9

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	9	NC_007120.7 (23813595..23824182, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	9	NC_007120.6 (24002726..24013313, complement)

Chromosome 9 - NC_007120.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in positive regulation of fat cell differentiation	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in early endosome	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: WD repeat and FYVE domain-containing protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_205745.1 → NP_991308.1 WD repeat and FYVE domain-containing protein 2

See identical proteins and their annotated locations for NP_991308.1

Status: PROVISIONAL

Source sequence(s)

AY394954

UniProtKB/TrEMBL

A0A8M1PGV5, Q6TLF1

Related

ENSDARP00000059208.4, ENSDART00000059209.5

Conserved Domains (4) summary

COG2319
Location:18 → 394

WD40; WD40 repeat [General function prediction only]

cd15718
Location:279 → 348

FYVE_WDFY1_like; FYVE domain found in WD40 repeat and FYVE domain-containing protein WDFY1 and WDFY2, and similar proteins

sd00039
Location:117 → 154

7WD40; WD40 repeat [structural motif]

cl02567
Location:16 → 272

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...