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    GAD1 glutamate decarboxylase 1 [ Pan troglodytes (chimpanzee) ]

    Gene ID: 468557, updated on 3-Dec-2024

    Summary

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    Official Symbol
    GAD1provided by VGNC
    Official Full Name
    glutamate decarboxylase 1provided by VGNC
    Primary source
    VGNC:VGNC:436
    Locus tag
    CK820_G0001462
    See related
    Ensembl:ENSPTRG00000012626
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Pan troglodytes
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
    Also known as
    GAD-67
    Orthologs
    human mouse all
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    Genomic context

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    See GAD1 in Genome Data Viewer
    Location:
    chromosome: 13
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current NHGRI_mPanTro3-v2.0_pri (GCF_028858775.2) 13 NC_072411.2 (72863103..72907614)
    RS_2023_04 previous assembly NHGRI_mPanTro3-v1.1-hic.freeze_pri (GCF_028858775.1) 2B NC_072400.1 (72863083..72907574)

    Chromosome 13 - NC_072411.2Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134807989 Neighboring gene uncharacterized LOC107973823 Neighboring gene Sp5 transcription factor Neighboring gene glutamate rich 2 Neighboring gene golgi reassembly stacking protein 2 Neighboring gene tousled like kinase 1 Neighboring gene uncharacterized LOC129143313

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Accelerated evolution of nervous system genes in the origin of Homo sapiens. Dorus S, et al. Cell, 2004 Dec 29. PMID 15620360
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables glutamate decarboxylase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables pyridoxal phosphate binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in gamma-aminobutyric acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in presynaptic active zone IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    glutamate decarboxylase 1
    Names
    67 kDa glutamic acid decarboxylase
    glutamate decarboxylase 1 (brain, 67kDa)
    NP_001029285.1
    XP_009441979.1
    XP_063646331.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001034113.1 → NP_001029285.1  glutamate decarboxylase 1

      See identical proteins and their annotated locations for NP_001029285.1

      Status: PROVISIONAL

      Source sequence(s)
      AY665260
      UniProtKB/Swiss-Prot
      Q5IS68
      UniProtKB/TrEMBL
      A0A2J8PQQ8
      Conserved Domains (1) summary
      pfam00282
      Location:144 → 518
      Pyridoxal_deC; Pyridoxal-dependent decarboxylase conserved domain

    RefSeqs of Annotated Genomes: GCF_028858775.2-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

    Genomic

    1. NC_072411.2 Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

      Range
      72863103..72907614
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063790261.1 → XP_063646331.1  glutamate decarboxylase 1 isoform X2

      UniProtKB/TrEMBL
      A0A2I3SMK4, A0A2I3TNB3, A0A2J8PQQ4, A0A2J8PQQ5, A0A6D2XYH8, A0A6D2Y4N6

    2. XM_009443704.3 → XP_009441979.1  glutamate decarboxylase 1 isoform X1

      See identical proteins and their annotated locations for XP_009441979.1

      UniProtKB/Swiss-Prot
      Q5IS68
      UniProtKB/TrEMBL
      A0A2J8PQQ8
      Related
      ENSPTRP00000021575.5
      Conserved Domains (1) summary
      pfam00282
      Location:144 → 518
      Pyridoxal_deC; Pyridoxal-dependent decarboxylase conserved domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5IS68.1 GenPept UniProtKB/Swiss-Prot:Q5IS68

    Gene LinkOut

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