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    Spn27A Serpin 27A [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 45815, updated on 17-Dec-2024

    Summary

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    Official Symbol
    Spn27Aprovided by FlyBase
    Official Full Name
    Serpin 27Aprovided by FlyBase
    Primary source
    FLYBASE:FBgn0028990
    Locus tag
    Dmel_CG11331
    See related
    AllianceGenome:FB:FBgn0028990
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG11331; Dm-Spn27A; Dmel\CG11331; EST1; sp27A; Sp27A; Spn27; spn27A; Spn27a
    Summary
    Enables serine-type endopeptidase inhibitor activity. Involved in several processes, including behavioral response to ethanol; defense response to other organism; and negative regulation of protein metabolic process. Located in perivitelline space. Is expressed in several structures, including adult head; embryonic hypopharynx; embryonic large intestine; extraembryonic structure; and gut section. Human ortholog(s) of this gene implicated in intermediate coronary syndrome; neurodegenerative disease (multiple); thrombophilia (multiple); thrombosis; and toxic shock syndrome. Orthologous to several human genes including SERPINA12 (serpin family A member 12); SERPINB1 (serpin family B member 1); and SERPINC1 (serpin family C member 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Spn27A in Genome Data Viewer
    Location:
    26F6-26F6; 2-21 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (6671065..6673347, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (6671065..6673347, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene cup Neighboring gene Galactose-1-phosphate uridylyltransferase Neighboring gene cortex Neighboring gene Non-SMC element 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Drosophila serpin 27A is a likely target for immune suppression of the blood cell-mediated melanotic encapsulation response. Nappi AJ, et al. J Insect Physiol, 2005 Feb. PMID 15749104
    2. Activation of insect phenoloxidase after injury: endogenous versus foreign elicitors. Bidla G, et al. J Innate Immun, 2009. PMID 20375588
    3. Actomyosin meshwork mechanosensing enables tissue shape to orient cell force. Chanet S, et al. Nat Commun, 2017 May 15. PMID 28504247, Free PMC Article
    4. Structural Redundancy in Supracellular Actomyosin Networks Enables Robust Tissue Folding. Yevick HG, et al. Dev Cell, 2019 Sep 9. PMID 31353314, Free PMC Article
    5. Actomyosin-based tissue folding requires a multicellular myosin gradient. Heer NC, et al. Development, 2017 May 15. PMID 28432215, Free PMC Article

    See all (98) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables serine-type endopeptidase inhibitor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables serine-type endopeptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine-type endopeptidase inhibitor activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in behavioral response to ethanol IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in defense response to fungus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in defense response to insect IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in dorsal/ventral pattern formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in melanization defense response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in melanotic encapsulation of foreign target IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation melanotic encapsulation of foreign target IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of Toll receptor ligand protein activation cascade IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of Toll receptor ligand protein activation cascade IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of melanization defense response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of proteolysis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in response to wounding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in perivitelline space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    serpin 27A
    Names
    CG11331-PA
    CG11331-PB
    Dm-serpin-27A
    Serpin-27A
    Serpin27A
    Spn27A-PA
    Spn27A-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      6671065..6673347 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001273214.1 → NP_001260143.1  serpin 27A, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260143.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9V3N1
      Conserved Domains (1) summary
      cd00172
      Location:72 → 440
      SERPIN; SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate ...

    2. NM_143767.3 → NP_652024.1  serpin 27A, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_652024.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9V3N1
      Related
      FBpp0078950
      Conserved Domains (1) summary
      cd00172
      Location:72 → 440
      SERPIN; SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9V3N1.1 Q9V3N1

    Gene LinkOut

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