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    mftA mycofactocin precursor MftA [ Mycobacterium canettii CIPT 140010059 ]

    Gene ID: 45428029, updated on 11-Dec-2024

    Summary

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    Gene symbol
    mftA
    Gene description
    mycofactocin precursor MftA
    Locus tag
    MCAN_RS22300
    Gene type
    protein coding
    Organism
    Mycobacterium canettii CIPT 140010059 (strain: CIPT 140010059)
    Lineage
    Bacteria; Bacillati; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
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    Genomic context

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    Sequence:
    NC_015848.1 (803574..803663)

    NC_015848.1Genomic Context describing neighboring genes Neighboring gene hypothetical protein Neighboring gene DUF2332 domain-containing protein Neighboring gene mycofactocin system transcriptional regulator Neighboring gene mycofactocin biosynthesis chaperone MftB Neighboring gene mycofactocin radical SAM maturase Neighboring gene pre-mycofactocin synthase MftD

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_015848.1

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. MftD Catalyzes the Formation of a Biologically Active Redox Center in the Biosynthesis of the Ribosomally Synthesized and Post-translationally Modified Redox Cofactor Mycofactocin. Ayikpoe RS, et al. J Am Chem Soc, 2019 Aug 28. PMID 31381312, Free PMC Article
    2. Mycofactocin biosynthesis: modification of the peptide MftA by the radical S-adenosylmethionine protein MftC. Khaliullin B, et al. FEBS Lett, 2016 Aug. PMID 27312813
    3. The Radical S-Adenosyl-l-methionine Enzyme MftC Catalyzes an Oxidative Decarboxylation of the C-Terminus of the MftA Peptide. Bruender NA, et al. Biochemistry, 2016 May 24. PMID 27158836, Free PMC Article
    4. Mycofactocin Is Associated with Ethanol Metabolism in Mycobacteria. Krishnamoorthy G, et al. mBio, 2019 May 21. PMID 31113891, Free PMC Article
    5. Bioinformatic evidence for a widely distributed, ribosomally produced electron carrier precursor, its maturation proteins, and its nicotinoprotein redox partners. Haft DH. BMC Genomics, 2011 Jan 11. PMID 21223593, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General protein information

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    Preferred Names
    mycofactocin precursor MftA
    WP_003403483.1
    • Mycofactocin is a small molecule electron carrier derived from the final two amino acids, Val-Tyr, of MftA, the mycofactocin precursor. It plays a role in redox homeostasis and the metabolism of alcohols and aldehydes in Actinobacteria, including Mycobacterium tuberculosis.

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_015848.1 Reference assembly

      Range
      803574..803663
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      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. WP_003403483.1 MULTISPECIES: mycofactocin precursor MftA [Mycobacteriaceae]

      See identical proteins and their annotated locations for WP_003403483.1

      UniProtKB/Swiss-Prot
      P0DJC2, P9WJ80, P9WJ81, Q8VKG2
      UniProtKB/TrEMBL
      A0A0E8NRR2, A0A7V9WE78, A0A829CI46, A0AAU0Q8N9, A0AAW8I277, A0AAX1PZX9
      Conserved Domains (1) summary
      TIGR03969
      Location:7 → 29
      mycofactocin; mycofactocin precursor