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    inhA NADH-dependent enoyl-ACP reductase InhA [ Mycobacterium canettii CIPT 140010059 ]

    Gene ID: 45425463, updated on 11-Dec-2024

    Summary

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    Gene symbol
    inhA
    Gene description
    NADH-dependent enoyl-ACP reductase InhA
    Locus tag
    MCAN_RS07900
    Gene type
    protein coding
    Organism
    Mycobacterium canettii CIPT 140010059 (strain: CIPT 140010059)
    Lineage
    Bacteria; Bacillati; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
    Old locus tag
    MCAN_15011
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    Genomic context

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    Sequence:
    NC_015848.1 (1698370..1699179)

    NC_015848.1Genomic Context describing neighboring genes Neighboring gene hypothetical protein Neighboring gene 3-oxoacyl-ACP reductase FabG1 Neighboring gene ferrochelatase Neighboring gene hypothetical protein Neighboring gene NfeD family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_015848.1

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. InhA, a target of the antituberculous drug isoniazid, is involved in a mycobacterial fatty acid elongation system, FAS-II. Marrakchi H, et al. Microbiology (Reading), 2000 Feb. PMID 10708367
    2. Roles of tyrosine 158 and lysine 165 in the catalytic mechanism of InhA, the enoyl-ACP reductase from Mycobacterium tuberculosis. Parikh S, et al. Biochemistry, 1999 Oct 12. PMID 10521269
    3. Crystal structure of the Mycobacterium tuberculosis enoyl-ACP reductase, InhA, in complex with NAD+ and a C16 fatty acyl substrate. Rozwarski DA, et al. J Biol Chem, 1999 May 28. PMID 10336454
    4. Genomic analysis of smooth tubercle bacilli provides insights into ancestry and pathoadaptation of Mycobacterium tuberculosis. Supply P, et al. Nat Genet, 2013 Feb. PMID 23291586, Free PMC Article
    5. The genome of Mycobacterium africanum West African 2 reveals a lineage-specific locus and genome erosion common to the M. tuberculosis complex. Bentley SD, et al. PLoS Negl Trop Dis, 2012. PMID 22389744, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    General protein information

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    Preferred Names
    NADH-dependent enoyl-ACP reductase InhA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_015848.1 Reference assembly

      Range
      1698370..1699179
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      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. WP_003407553.1 MULTISPECIES: NADH-dependent enoyl-ACP reductase InhA [Mycobacterium]

      See identical proteins and their annotated locations for WP_003407553.1

      UniProtKB/Swiss-Prot
      A0A1R3Y0K6, F2GEM2, P0A5Y6, P0A5Y7, P46533, P9WGR0, P9WGR1, Q540M9, X2BIC8
      UniProtKB/TrEMBL
      A0A0H3LFJ7, A0A0H3M400, A0A679LDV0, A0A829CBJ4, A0AAU0QBI2, A0AAW8I658, A5U2I8, M9TGV3
      Conserved Domains (1) summary
      PRK07889
      Location:1 → 269
      PRK07889; enoyl-[acyl-carrier-protein] reductase FabI
    Nucleotide Protein
    Heading Accession and Version

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