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    INPPL1 inositol polyphosphate phosphatase like 1 [ Pan troglodytes (chimpanzee) ]

    Gene ID: 451403, updated on 3-Dec-2024

    Summary

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    Official Symbol
    INPPL1provided by VGNC
    Official Full Name
    inositol polyphosphate phosphatase like 1provided by VGNC
    Primary source
    VGNC:VGNC:3251
    Locus tag
    CK820_G0047596
    See related
    Ensembl:ENSPTRG00000004031
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Pan troglodytes
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
    Orthologs
    human mouse all
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    Genomic context

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    See INPPL1 in Genome Data Viewer
    Location:
    chromosome: 9
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    RS_2024_02 current NHGRI_mPanTro3-v2.0_pri (GCF_028858775.2) 9 NC_072407.2 (74257496..74272759)
    RS_2023_04 previous assembly NHGRI_mPanTro3-v1.1-hic.freeze_pri (GCF_028858775.1) 11 NC_072409.1 (73359923..73375584)

    Chromosome 9 - NC_072407.2Genomic Context describing neighboring genes Neighboring gene folate receptor alpha Neighboring gene folate receptor beta Neighboring gene paired like homeobox 2A Neighboring gene uncharacterized LOC107967152 Neighboring gene docking protein 1-like Neighboring gene splicing factor U2AF 35 kDa subunit-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables inositol-polyphosphate 5-phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of insulin-like growth factor receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in phosphatidylinositol dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of immune response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_028858775.2-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

    Genomic

    1. NC_072407.2 Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

      Range
      74257496..74272759
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063784305.1 → XP_063640375.1  phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 isoform X3

      UniProtKB/TrEMBL
      A0A2I3TQD0, A0A2J8PZT3, A0A6D2WIY2

    2. XM_508622.8 → XP_508622.2  phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 isoform X2

      See identical proteins and their annotated locations for XP_508622.2

      UniProtKB/TrEMBL
      A0A2I3SUQ8, A0A2J8PZT8, A0A6D2WFI3, H2Q4C6
      Related
      ENSPTRP00000006936.3
      Conserved Domains (5) summary
      cd09491
      Location:1194 → 1256
      SAM_Ship2; SAM domain of Ship2 lipid phosphatase proteins
      cd09101
      Location:424 → 727
      INPP5c_SHIP2-INPPL1; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of SH2 domain containing inositol 5-phosphatase-2 and related proteins
      cd10343
      Location:17 → 119
      SH2_SHIP; Src homology 2 (SH2) domain found in SH2-containing inositol-5'-phosphatase (SHIP) and SLAM-associated protein (SAP)
      cl25800
      Location:902 → 1046
      GGN; Gametogenetin
      cl27966
      Location:93 → 181
      MinC; Septum formation inhibitor MinC [Cell cycle control, cell division, chromosome partitioning]

    3. XM_009423712.5 → XP_009421987.1  phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 isoform X4

      See identical proteins and their annotated locations for XP_009421987.1

      UniProtKB/TrEMBL
      A0A2I3SUQ8
      Conserved Domains (4) summary
      cd09491
      Location:1216 → 1278
      SAM_Ship2; SAM domain of Ship2 lipid phosphatase proteins
      cd09101
      Location:446 → 749
      INPP5c_SHIP2-INPPL1; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of SH2 domain containing inositol 5-phosphatase-2 and related proteins
      smart00454
      Location:1224 → 1280
      SAM; Sterile alpha motif
      cd10343
      Location:17 → 119
      SH2_SHIP; Src homology 2 (SH2) domain found in SH2-containing inositol-5'-phosphatase (SHIP) and SLAM-associated protein (SAP)

    4. XM_054662534.2 → XP_054518509.1  phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 isoform X1

      UniProtKB/TrEMBL
      A0A2J8PZU9
    Nucleotide Protein
    Heading Accession and Version

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