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    clbC colibactin polyketide synthase ClbC [ Citrobacter koseri ATCC BAA-895 ]

    Gene ID: 45135052, updated on 3-Dec-2024

    Summary

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    Gene symbol
    clbC
    Gene description
    colibactin polyketide synthase ClbC
    Locus tag
    CKO_RS03755
    Gene type
    protein coding
    Organism
    Citrobacter koseri ATCC BAA-895 (strain: ATCC BAA-895)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Citrobacter
    Old locus tag
    CKO_00860
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    Genomic context

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    Sequence:
    NC_009792.1 (829173..831773)

    NC_009792.1Genomic Context describing neighboring genes Neighboring gene colibactin biosynthesis LuxR family transcriptional regulator ClbR Neighboring gene colibactin hybrid non-ribosomal peptide synthetase/type I polyketide synthase ClbB Neighboring gene colibactin biosynthesis dehydrogenase ClbD Neighboring gene colibactin biosynthesis aminomalonyl-acyl carrier protein ClbE

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_009792.1

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Gut symbionts from distinct hosts exhibit genotoxic activity via divergent colibactin biosynthesis pathways. Engel P, et al. Appl Environ Microbiol, 2015 Feb. PMID 25527542, Free PMC Article
    2. Escherichia coli induces DNA double-strand breaks in eukaryotic cells. Nougayrède JP, et al. Science, 2006 Aug 11. PMID 16902142

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    General protein information

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    Preferred Names
    colibactin polyketide synthase ClbC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_009792.1 Reference assembly

      Range
      829173..831773
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      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. WP_001297908.1 MULTISPECIES: colibactin polyketide synthase ClbC [Enterobacterales]

      See identical proteins and their annotated locations for WP_001297908.1

      UniProtKB/TrEMBL
      A0A0J2FZE1, A0A1C1IWY9, A0A454A565, A0AAQ0VDA3, A0AAW9DXQ1, Q0P7J3, S1P918
      Conserved Domains (2) summary
      cd00833
      Location:10 → 431
      PKS; polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or ...
      pfam00550
      Location:787 → 846
      PP-binding; Phosphopantetheine attachment site

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