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    phf20b PHD finger protein 20, b [ Danio rerio (zebrafish) ]

    Gene ID: 445482, updated on 9-Dec-2024

    Summary

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    Official Symbol
    phf20bprovided by ZNC
    Official Full Name
    PHD finger protein 20, bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040822-33
    See related
    Ensembl:ENSDARG00000038737 AllianceGenome:ZFIN:ZDB-GENE-040822-33
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:91986
    Summary
    Predicted to enable metal ion binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within regulation of DNA-templated transcription. Predicted to be located in nucleus. Predicted to be part of MLL1 complex and NSL complex. Is expressed in liver; telencephalon; and yolk syncytial layer. Orthologous to human PHF20 (PHD finger protein 20). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See phf20b in Genome Data Viewer
    Location:
    chromosome: 23
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 23 NC_007134.7 (14992800..15036772, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 23 NC_007134.6 (15236723..15280739, complement)

    Chromosome 23 - NC_007134.7Genomic Context describing neighboring genes Neighboring gene Src like adaptor 2b Neighboring gene ndrg family member 3b Neighboring gene Rho GTPase activating protein 46b Neighboring gene sulfatase 2b Neighboring gene uncharacterized LOC137489105

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Transcriptomic profiles of tumor-associated neutrophils reveal prominent roles in enhancing angiogenesis in liver tumorigenesis in zebrafish. Huo X, et al. Sci Rep, 2019 Feb 6. PMID 30728369, Free PMC Article
    2. Drug screening in Scn1a zebrafish mutant identifies clemizole as a potential Dravet syndrome treatment. Baraban SC, et al. Nat Commun, 2013. PMID 24002024, Free PMC Article
    3. Dhx38 is required for the maintenance and differentiation of erythro-myeloid progenitors and hematopoietic stem cells by alternative splicing. Tu J, et al. Development, 2022 Sep 1. PMID 35929537
    4. A network of epigenetic regulators guides developmental haematopoiesis in vivo. Huang HT, et al. Nat Cell Biol, 2013 Dec. PMID 24240475, Free PMC Article
    5. Comprehensive expression map of transcription regulators in the adult zebrafish telencephalon reveals distinct neurogenic niches. Diotel N, et al. J Comp Neurol, 2015 Jun 1. PMID 25556858, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    PHD finger protein 20b

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001004114.1 → NP_001004114.1  PHD finger protein 20b

      See identical proteins and their annotated locations for NP_001004114.1

      Status: PROVISIONAL

      Source sequence(s)
      BC080250
      UniProtKB/TrEMBL
      A0A8M1N229, Q68EI2
      Related
      ENSDARP00000056569.4, ENSDART00000056570.5
      Conserved Domains (3) summary
      cd04508
      Location:90 → 135
      TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...
      cd15634
      Location:618 → 661
      PHD_PHF20; PHD finger found in PHD finger protein 20 (PHF20)
      cl17705
      Location:1 → 68
      MBT; mbt repeat

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007134.7 Reference GRCz11 Primary Assembly

      Range
      14992800..15036772 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005161993.5 → XP_005162050.1  PHD finger protein 20b isoform X1

      UniProtKB/TrEMBL
      A0A8M2B947
      Conserved Domains (3) summary
      cd04508
      Location:90 → 135
      TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...
      cd15634
      Location:662 → 705
      PHD_PHF20; PHD finger found in PHD finger protein 20 (PHF20)
      cl17705
      Location:1 → 68
      MBT; mbt repeat

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018395137.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      21342..65301 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCz11 ALT_DRER_TU_2

    Genomic

    1. NW_018395359.1 Reference GRCz11 ALT_DRER_TU_2

      Range
      21342..65301 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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