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    chrne cholinergic receptor, nicotinic, epsilon [ Danio rerio (zebrafish) ]

    Gene ID: 445315, updated on 4-Jan-2025

    Summary

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    Official Symbol
    chrneprovided by ZNC
    Official Full Name
    cholinergic receptor, nicotinic, epsilonprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040808-32
    See related
    Ensembl:ENSDARG00000034307 AllianceGenome:ZFIN:ZDB-GENE-040808-32
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    im:7154697; zgc:101010
    Summary
    Contributes to acetylcholine receptor activity. Acts upstream of or within cellular response to acetylcholine and cholinergic synaptic transmission. Part of acetylcholine-gated channel complex. Is expressed in central nervous system; mesoderm; musculature system; and somite. Human ortholog(s) of this gene implicated in congenital myasthenic syndrome; congenital myasthenic syndrome 4A; congenital myasthenic syndrome 4B; and congenital myasthenic syndrome 4C. Orthologous to human CHRNE (cholinergic receptor nicotinic epsilon subunit). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    all
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    Genomic context

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    See chrne in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (38440099..38451115, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (37839946..37850962, complement)

    Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene misshapen-like kinase 1 Neighboring gene uncharacterized LOC137490148 Neighboring gene phospholipase D2 Neighboring gene glycolipid transfer protein domain containing 2b Neighboring gene uncharacterized LOC101885954 Neighboring gene ATPase Na+/K+ transporting subunit beta 2b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. High-speed camera recordings uncover previously unidentified elements of zebrafish mating behaviors integral to successful fertilization. Zempo B, et al. Sci Rep, 2021 Oct 12. PMID 34642406, Free PMC Article
    2. Synaptic silencing of fast muscle is compensated by rewired innervation of slow muscle. Zempo B, et al. Sci Adv, 2020 Apr. PMID 32284992, Free PMC Article
    3. Early Exposure to THC Alters M-Cell Development in Zebrafish Embryos. Amin MR, et al. Biomedicines, 2020 Jan 4. PMID 31947970, Free PMC Article
    4. A single mutation in the acetylcholine receptor δ-subunit causes distinct effects in two types of neuromuscular synapses. Park JY, et al. J Neurosci, 2014 Jul 30. PMID 25080583, Free PMC Article
    5. An acetylcholine receptor lacking both γ and ε subunits mediates transmission in zebrafish slow muscle synapses. Mongeon R, et al. J Gen Physiol, 2011 Sep. PMID 21844221, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    contributes_to acetylcholine receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables acetylcholine-gated monoatomic cation-selective channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables acetylcholine-gated monoatomic cation-selective channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables extracellular ligand-gated monoatomic ion channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables monoatomic ion channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmembrane signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in acetylcholine receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within cellular response to acetylcholine IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in chemical synaptic transmission IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in membrane depolarization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in monoatomic ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within monoatomic ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within synaptic transmission, cholinergic IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of acetylcholine-gated channel complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of acetylcholine-gated channel complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in postsynaptic membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    acetylcholine receptor subunit epsilon
    Names
    AChR epsilon
    nicotinic acetylcholine receptor subunit epsilon

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001327883.1 → NP_001314812.1  acetylcholine receptor subunit epsilon precursor

      Status: PROVISIONAL

      Source sequence(s)
      BX324194, CR854980
      UniProtKB/TrEMBL
      A0A8M1P9H7, A2BG85, F1REB2
      Related
      ENSDARP00000116514.1, ENSDART00000136428.3
      Conserved Domains (3) summary
      TIGR00860
      Location:10 → 495
      LIC; Cation transporter family protein
      pfam02931
      Location:29 → 245
      Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
      pfam02932
      Location:252 → 494
      Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007116.7 Reference GRCz11 Primary Assembly

      Range
      38440099..38451115 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394597.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      173955..184555 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001003772.1: Suppressed sequence

      Description
      NM_001003772.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

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