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    paics.S phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase S homeolog [ Xenopus laevis (African clawed frog) ]

    Gene ID: 444677, updated on 9-Dec-2024

    Summary

    Official Symbol
    paics.S
    Official Full Name
    phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase S homeolog
    Primary source
    Xenbase:XB-GENE-965998
    Locus tag
    XELAEV_18009081mg
    See related
    EnsemblRapid:ENSXLAG00005029760 AllianceGenome:Xenbase:XB-GENE-965998
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Xenopus laevis
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
    Also known as
    ade2; airc; pais; paics.1; paics.1.S
    Summary
    Predicted to enable ATP binding activity; phosphoribosylaminoimidazole carboxylase activity; and phosphoribosylaminoimidazolesuccinocarboxamide synthase activity. Predicted to act upstream of or within 'de novo' IMP biosynthetic process. Predicted to be located in cytosol. Human ortholog(s) of this gene implicated in schizophrenia. Orthologous to human PAICS (phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See paics.S in Genome Data Viewer
    Location:
    chromosome: 1S
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 1S NC_054372.1 (29930728..29944400)
    100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 1S NC_030725.1 (29825972..29839738)

    Chromosome 1S - NC_054372.1Genomic Context describing neighboring genes Neighboring gene exocyst complex component 1 S homeolog Neighboring gene capping protein inhibiting regulator of actin dynamics S homeolog Neighboring gene phosphoribosyl pyrophosphate amidotransferase S homeolog Neighboring gene LON peptidase N-terminal domain and RING finger protein 1

    Genomic regions, transcripts, and products

    General protein information

    Preferred Names
    phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazolesuccinocarboxamide synthase S homeolog
    Names
    phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase, gene 1
    phosphoribosylaminoimidazole carboxylase; phosphoribosylaminoimidazolesuccinocarboxamide synthase S homeolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001092779.1NP_001086248.1  phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazolesuccinocarboxamide synthase S homeolog

      See identical proteins and their annotated locations for NP_001086248.1

      Status: PROVISIONAL

      Source sequence(s)
      BC074374
      UniProtKB/TrEMBL
      A0A974DSY7, Q6GLT0
      Related
      ENSXLAP00005089471.1, ENSXLAT00005091140.1
      Conserved Domains (2) summary
      cd01416
      Location:7258
      SAICAR_synt_Ade5; Ade5_like 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase
      TIGR01162
      Location:268421
      purE; phosphoribosylaminoimidazole carboxylase, PurE protein

    RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Xenopus_laevis_v10.1 Primary Assembly

    Genomic

    1. NC_054372.1 Reference Xenopus_laevis_v10.1 Primary Assembly

      Range
      29930728..29944400
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)