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    MIAT myocardial infarction associated transcript [ Homo sapiens (human) ]

    Gene ID: 440823, updated on 10-Dec-2024

    Summary

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    Official Symbol
    MIATprovided by HGNC
    Official Full Name
    myocardial infarction associated transcriptprovided by HGNC
    Primary source
    HGNC:HGNC:33425
    See related
    Ensembl:ENSG00000225783 MIM:611082; AllianceGenome:HGNC:33425
    Gene type
    ncRNA
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RNCR2; GOMAFU; C22orf35; LINC00066; NCRNA00066; lncRNA-MIAT
    Summary
    This gene encodes a spliced long non-coding RNA that may constitute a component of the nuclear matrix. Altered expression of this locus has been reported to be associated with a susceptibility to myocardial infarction. It has also been proposed that pathways involving this transcript may contribute to the pathophysiology of schizophrenia. A similar gene in mouse has been associated with retinal cell fate determination. Alternatively spliced transcript variants have been identified. [provided by RefSeq, Dec 2014]
    Expression
    Biased expression in brain (RPKM 36.1), adrenal (RPKM 14.9) and 11 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See MIAT in Genome Data Viewer
    Location:
    22q12.1
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 22 NC_000022.11 (26646429..26676478)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 22 NC_060946.1 (27109028..27139053)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (27042393..27072441)

    Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:27003362-27004004 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18796 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13574 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr22:27009656-27010334 Neighboring gene crystallin beta A4 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:27013045-27013722 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:27014401-27015076 Neighboring gene crystallin beta B1 Neighboring gene CRISPRi-validated cis-regulatory element chr22.1058 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:27037805-27038669 Neighboring gene Sharpr-MPRA regulatory region 8650 Neighboring gene Sharpr-MPRA regulatory region 12592 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:27041123-27041688 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:27043802-27044604 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:27045408-27046209 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13576 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18797 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr22:27057049-27058028 Neighboring gene H3K27ac hESC enhancer GRCh37_chr22:27061097-27061597 Neighboring gene iron-sulfur cluster assembly 2 pseudogene 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:27063956-27064539 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:27064540-27065122 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:27076707-27077531 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:27077532-27078355 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr22:27085634-27086255 Neighboring gene MIAT neighbor Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18798 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18799 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:27146977-27147974 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:27147975-27148973 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:27148974-27149971 Neighboring gene Sharpr-MPRA regulatory region 13066 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr22:27179387-27180586 Neighboring gene Sharpr-MPRA regulatory region 7329 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:27196413-27196924 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18800 Neighboring gene Sharpr-MPRA regulatory region 5469 Neighboring gene uncharacterized LOC110091768 Neighboring gene ribosomal protein L15 pseudogene 22

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. MIAT promotes proliferation and hinders apoptosis by modulating miR-181b/STAT3 axis in ox-LDL-induced atherosclerosis cell models. Zhong X, et al. Biomed Pharmacother, 2018 Jan. PMID 29136944
    2. Chlamydia trachomatis induces lncRNA MIAT upregulation to regulate mitochondria-mediated host cell apoptosis and chlamydial development. Luo F, et al. J Cell Mol Med, 2022 Jan. PMID 34859581, Free PMC Article
    3. Upregulation of long noncoding RNA MIAT in aggressive form of chronic lymphocytic leukemias. Sattari A, et al. Oncotarget, 2016 Aug 23. PMID 27527866, Free PMC Article
    4. Upregulation of long non-coding RNA myocardial infarction-associated transcription is correlated with coronary artery stenosis and elevated inflammation in patients with coronary atherosclerotic heart disease. Yan ZS, et al. Kaohsiung J Med Sci, 2021 Dec. PMID 34558803
    5. Long non-coding RNA MIAT knockdown promotes osteogenic differentiation of human adipose-derived stem cells. Jin C, et al. Cell Biol Int, 2017 Jan. PMID 27797128

    See all (95) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Diagnostic significance of LncRNA MIAT in periodontitis and the molecular mechanisms influencing periodontal ligament fibroblasts via the miR-204-5p/DKK1 axis.
      Title: Diagnostic significance of LncRNA MIAT in periodontitis and the molecular mechanisms influencing periodontal ligament fibroblasts via the miR-204-5p/DKK1 axis.
    2. MIAT promotes myofibroblastic activities and transformation in oral submucous fibrosis through sponging the miR-342-3p/SOX6 axis.
      Title: MIAT promotes myofibroblastic activities and transformation in oral submucous fibrosis through sponging the miR-342-3p/SOX6 axis.
    3. Exosomal lncRNA-MIAT promotes neovascularization via the miR-133a-3p/MMP-X1 axis in diabetic retinopathy.
      Title: Exosomal lncRNA-MIAT promotes neovascularization via the miR-133a-3p/MMP-X1 axis in diabetic retinopathy.
    4. lncRNA-MIAT rs9625066 polymorphism could be a potential biomarker for ischemic stroke.
      Title: lncRNA-MIAT rs9625066 polymorphism could be a potential biomarker for ischemic stroke.
    5. LncRNA MIAT Modulates LPS-Induced Acute Kidney Injury via BECN1-Dependent Autophagy by Interacting with PTBP1.
      Title: LncRNA MIAT Modulates LPS-Induced Acute Kidney Injury via BECN1-Dependent Autophagy by Interacting with PTBP1.
    6. MIAT shuttled by tumor-secreted exosomes promotes paclitaxel resistance in esophageal cancer cells by activating the TAF1/SREBF1 axis.
      Title: MIAT shuttled by tumor-secreted exosomes promotes paclitaxel resistance in esophageal cancer cells by activating the TAF1/SREBF1 axis.
    7. Long noncoding RNA MIAT regulates TP53 ubiquitination and expedites prostate adenocarcinoma progression by recruiting TBL1X.
      Title: Long noncoding RNA MIAT regulates TP53 ubiquitination and expedites prostate adenocarcinoma progression by recruiting TBL1X.
    8. The human lncRNA GOMAFU suppresses neuronal interferon response pathways affected in neuropsychiatric diseases.
      Title: The human lncRNA GOMAFU suppresses neuronal interferon response pathways affected in neuropsychiatric diseases.
    9. LncRNA-MIAT activates hepatic stellate cells via regulating Hippo pathway and epithelial-to-mesenchymal transition.
      Title: LncRNA-MIAT activates hepatic stellate cells via regulating Hippo pathway and epithelial-to-mesenchymal transition.
    10. The LncRNA MIAT is identified as a regulator of stemness-associated transcript in glioma.
      Title: The LncRNA MIAT is identified as a regulator of stemness-associated transcript in glioma.
    Submit: New GeneRIF Correction See all GeneRIFs (86)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Associated conditions

    Description Tests
    Myocardial infarction, susceptibility to
    MedGen: C1832662 OMIM: 608446 GeneReviews: Not available
    		Compare labs

    EBI GWAS Catalog

    Description
    Genes linked to energy metabolism and immunoregulatory mechanisms are associated with subcutaneous adipose tissue distribution in HIV-infected men.
    EBI GWAS Catalog
    Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Other Names

    • MI related novel mRNA
    • long intergenic non-protein coding RNA 66
    • myocardial infarction associated transcript (non-protein coding)

    Clone Names

    • FLJ25887, FLJ25967, FLJ38367, FLJ45323

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_016621.2 RefSeqGene

      Range
      5001..23997
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. NR_003491.4 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      KF511428, Z99774
      Related
      ENST00000613780.4

    2. NR_033319.3 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      KF511428, Z99774
      Related
      ENST00000616469.4

    3. NR_033320.3 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      KF511428, Z99774
      Related
      ENST00000620145.6

    4. NR_033321.3 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      KF511428, Z99774
      Related
      ENST00000616213.4

    5. NR_185982.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      KF511428, Z99774

    6. NR_185983.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      KF511428, Z99774

    7. NR_185984.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      KF511428, Z99774

    8. NR_185985.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      KF511428, Z99774

    9. NR_185986.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      KF511428, Z99774

    10. NR_185987.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      KF511428, Z99774

    11. NR_185988.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      KF511428, Z99774

    12. NR_185989.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      KF511428, Z99774

    13. NR_185990.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      KF511428, Z99774

    14. NR_185991.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      KF511428, Z99774

    15. NR_185993.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      KF511428, Z99774

    16. NR_185994.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      KF511428, Z99774

    17. NR_185995.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      KF511428, Z99774

    18. NR_185996.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      KF511428, Z99774

    19. NR_185997.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      KF511428, Z99774

    20. NR_185998.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      KF511428, Z99774

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000022.11 Reference GRCh38.p14 Primary Assembly

      Range
      26646429..26676478
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060946.1 Alternate T2T-CHM13v2.0

      Range
      27109028..27139053
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

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