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    Septin5 Septin 5 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43990, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Septin5provided by FlyBase
    Official Full Name
    Septin 5provided by FlyBase
    Primary source
    FLYBASE:FBgn0026361
    Locus tag
    Dmel_CG2916
    See related
    AllianceGenome:FB:FBgn0026361
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG2916; Dmel\CG2916; dSEPT5; Sep; sep5; Sep5
    Summary
    Predicted to enable GTPase activity and molecular adaptor activity. Involved in imaginal disc-derived wing morphogenesis and regulation of cell cycle. Predicted to be part of septin complex. Predicted to be active in cell division site; microtubule cytoskeleton; and septin ring. Is expressed in several structures, including anterior endoderm; dorsal ectoderm anlage; endoderm anlage; foregut anlage; and mesoderm. Orthologous to human SEPTIN10 (septin 10). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Septin5 in Genome Data Viewer
    Location:
    43F8-43F8; 2-57 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (7960133..7961921, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (3847638..3849426, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene ahuizotl Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene spenito Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Drosophila melanogaster septin gene Sep2 has a redundant function with the retrogene Sep5 in imaginal cell proliferation but is essential for oogenesis. O'Neill RS, et al. Genome, 2013 Dec. PMID 24433211
    2. Conservation and divergence of the G-interfaces of Drosophila melanogaster septins. de Freitas Fernandes A, et al. Cytoskeleton (Hoboken), 2023 Jul-Aug. PMID 36576069
    3. Septins From Protists to People. Shuman B, et al. Front Cell Dev Biol, 2021. PMID 35111763, Free PMC Article
    4. Septins regulate the contractility of the actomyosin ring to enable adherens junction remodeling during cytokinesis of epithelial cells. Founounou N, et al. Dev Cell, 2013 Feb 11. PMID 23410939
    5. Evolution of three parent genes and their retrogene copies in Drosophila species. O'Neill RS, et al. Int J Evol Biol, 2013. PMID 23841016, Free PMC Article

    See all (66) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. It has been found that Sep2 is uniquely required for follicle cell encapsulation of female germline cysts, and that Sep2 and Sep5 are redundant for follicle cell proliferation.
      Title: Partial Functional Diversification of Drosophila melanogaster Septin Genes Sep2 and Sep5.
    2. Results show that Sep2 Sep5 double mutants have an early pupal lethal phenotype and lack imaginal discs, suggesting that these genes have redundant functions during imaginal cell proliferation.
      Title: The Drosophila melanogaster septin gene Sep2 has a redundant function with the retrogene Sep5 in imaginal cell proliferation but is essential for oogenesis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables molecular adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cytoskeleton-dependent cytokinesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in imaginal disc development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in imaginal disc-derived wing morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of cell cycle IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cell division site IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in microtubule cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of septin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in septin ring IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    septin 5
    Names
    CG2916-PA
    CG2916-PB
    Sep5
    Septin-5
    Septin5-PA
    Septin5-PB
    septin

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      7960133..7961921 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_143704.3 → NP_651961.1  septin 5, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651961.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C7LAA7, Q7KLG8
      Related
      FBpp0087952
      Conserved Domains (3) summary
      cd01850
      Location:43 → 311
      CDC_Septin; CDC/Septin GTPase family
      COG5019
      Location:25 → 394
      CDC3; Septin family protein [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
      cl12013
      Location:252 → 405
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    2. NM_165578.3 → NP_724632.1  septin 5, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724632.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C7LAA7, Q7KLG8
      Related
      FBpp0087953
      Conserved Domains (3) summary
      cd01850
      Location:43 → 311
      CDC_Septin; CDC/Septin GTPase family
      COG5019
      Location:25 → 394
      CDC3; Septin family protein [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
      cl12013
      Location:252 → 405
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7KLG8 Q7KLG8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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