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    Serpinb6e serine (or cysteine) peptidase inhibitor, clade B, member 6e [ Mus musculus (house mouse) ]

    Gene ID: 435350, updated on 9-Dec-2024

    Summary

    Official Symbol
    Serpinb6eprovided by MGI
    Official Full Name
    serine (or cysteine) peptidase inhibitor, clade B, member 6eprovided by MGI
    Primary source
    MGI:MGI:2667778
    See related
    Ensembl:ENSMUSG00000069248 AllianceGenome:MGI:2667778
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    SPI3B; Gm11396; ovalbumin
    Summary
    Predicted to enable protease binding activity and serine-type endopeptidase inhibitor activity. Predicted to be involved in cellular response to osmotic stress; negative regulation of endopeptidase activity; and sensory perception of sound. Predicted to be part of serine protease inhibitor complex. Predicted to be active in cytoplasm and extracellular space. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 91. Orthologous to human SERPINB6 (serpin family B member 6). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Low expression observed in reference dataset See more
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    Genomic context

    See Serpinb6e in Genome Data Viewer
    Location:
    13 A3.3; 13 13.98 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (34016328..34027391, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (33832345..33843408, complement)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene serine (or cysteine) peptidase inhibitor, clade B pseudogene Neighboring gene STARR-seq mESC enhancer starr_34128 Neighboring gene serine (or cysteine) peptidase inhibitor, clade B, member 6d pseudogene Neighboring gene vomeronasal 2, receptor, pseudogene 94 Neighboring gene STARR-seq mESC enhancer starr_34130 Neighboring gene STARR-seq mESC enhancer starr_34131 Neighboring gene serine (or cysteine) peptidase inhibitor, clade B, member 6c Neighboring gene STARR-seq mESC enhancer starr_34132 Neighboring gene serine (or cysteine) peptidase inhibitor, clade B, member 6a Neighboring gene RIKEN cDNA 1110046J04 gene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protease binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables serine-type endopeptidase inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables serine-type endopeptidase inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in cellular response to osmotic stress ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in sensory perception of sound ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of serine protease inhibitor complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    serine (or cysteine) peptidase inhibitor, clade B, member 6e
    Names
    novel serine (or cysteine) proteinase inhibitor, clade B (Serpinb) member
    serine (or cysteine) proteinase inhibitor, clade B, member 6e

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001045535.2NP_001039000.2  serine (or cysteine) peptidase inhibitor, clade B, member 6e

      See identical proteins and their annotated locations for NP_001039000.2

      Status: VALIDATED

      Source sequence(s)
      AL450406
      Consensus CDS
      CCDS26440.2
      UniProtKB/TrEMBL
      I7HJI3
      Related
      ENSMUSP00000105904.2, ENSMUST00000110275.8
      Conserved Domains (1) summary
      cl38926
      Location:53429
      serpin; SERine Proteinase INhibitors (serpin) family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      34016328..34027391 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011244319.2XP_011242621.1  serine (or cysteine) peptidase inhibitor, clade B, member 6e isoform X1

      See identical proteins and their annotated locations for XP_011242621.1

      UniProtKB/TrEMBL
      I7HJI3
      Conserved Domains (1) summary
      cl38926
      Location:53429
      serpin; SERine Proteinase INhibitors (serpin) family