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    FipoQ F-box involved in polyQ pathogenesis [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43475, updated on 9-Dec-2024

    Summary

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    Official Symbol
    FipoQprovided by FlyBase
    Official Full Name
    F-box involved in polyQ pathogenesisprovided by FlyBase
    Primary source
    FLYBASE:FBgn0039667
    Locus tag
    Dmel_CG2010
    See related
    AllianceGenome:FB:FBgn0039667
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG2010; Dmel\CG2010; FBXL3
    Summary
    Involved in positive regulation of protein ubiquitination. Predicted to be part of SCF ubiquitin ligase complex. Is expressed in adult head; dorsal pharyngeal muscle cell; larval muscle system; larval somatic muscle cell; and larval visceral muscle cell. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See FipoQ in Genome Data Viewer
    Location:
    99B1-99B1; 3-99 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (29494782..29498923)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (25320504..25324645)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene diedel Neighboring gene TRC8 ring finger protein Neighboring gene NADH dehydrogenase (ubiquinone) 20 kDa subunit-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Drosophila signal peptidase complex member Spase12 is required for development and cell differentiation. Haase Gilbert E, et al. PLoS One, 2013. PMID 23573290, Free PMC Article
    2. FipoQ/FBXO33, a Cullin-1-based ubiquitin ligase complex component modulates ubiquitination and solubility of polyglutamine disease protein. Chen ZS, et al. J Neurochem, 2019 Jun. PMID 30685895
    3. A conserved F-box gene with unusual transcript localization. Das T, et al. Dev Genes Evol, 2002 Apr. PMID 11976951
    4. F-box proteins: the key to protein degradation. Ho MS, et al. J Biomed Sci, 2006 Mar. PMID 16463014
    5. A systematic phenotypic screen of F-box genes through a tissue-specific RNAi-based approach in Drosophila. Dui W, et al. J Genet Genomics, 2012 Aug 20. PMID 22884096

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process ISM
    Inferred from Sequence Model
    more info
    		  
    involved_in positive regulation of protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of protein ubiquitination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of SCF ubiquitin ligase complex ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    F-box involved in polyQ pathogenesis
    Names
    CG2010-PA
    CG2010-PB
    CG2010-PC
    FipoQ-PA
    FipoQ-PB
    FipoQ-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      29494782..29498923
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_143439.3 → NP_651696.1  F-box involved in polyQ pathogenesis, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651696.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IGU5, Q8T0K1
      Related
      FBpp0084795
      Conserved Domains (2) summary
      sd00034
      Location:215 → 240
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam12937
      Location:30 → 76
      F-box-like; F-box-like

    2. NM_001276140.1 → NP_001263069.1  F-box involved in polyQ pathogenesis, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001263069.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IGU5, Q8T0K1
      Conserved Domains (2) summary
      sd00034
      Location:215 → 240
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam12937
      Location:30 → 76
      F-box-like; F-box-like

    3. NM_170412.2 → NP_733291.1  F-box involved in polyQ pathogenesis, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_733291.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IGU5, Q9VAK7
      Related
      FBpp0084796
      Conserved Domains (2) summary
      sd00034
      Location:219 → 244
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam12937
      Location:34 → 80
      F-box-like; F-box-like
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8IGU5 Q8IGU5
    Q8T0K1 Q8T0K1
    Q9VAK7 Q9VAK7

    Gene LinkOut

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