Sirt7 Sirtuin 7 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Sirt7provided by FlyBase
Official Full Name: Sirtuin 7provided by FlyBase
Primary source: FLYBASE:FBgn0039631
Locus tag: Dmel_CG11305
See related: AllianceGenome:FB:FBgn0039631
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG11305; D.mel5; Dmel\CG11305; dmSRT409; dSIRT7; SIRT7
Summary: Predicted to enable NAD+ binding activity; histone H3K18 deacetylase activity, NAD-dependent; and hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides. Predicted to be located in chromatin. Predicted to be active in nucleus. Is expressed in spermatozoon. Orthologous to human SIRT7 (sirtuin 7). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (29055927..29059204)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (24881649..24884926)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Preparation of polyclonal antibodies against the Drosophila deacetylases SIRT 6 and SIRT 7.
Title: Preparation of polyclonal antibodies against the Drosophila deacetylases SIRT 6 and SIRT 7.

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables NAD+ binding	IBA Inferred from Biological aspect of Ancestor more info
enables NAD+ binding	IEA Inferred from Electronic Annotation more info
enables histone H3K18 deacetylase activity, NAD-dependent	IBA Inferred from Biological aspect of Ancestor more info
enables histone deacetylase activity, NAD-dependent	NAS Non-traceable Author Statement more info	PubMed
enables protein-glutaryllysine deglutarylase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein-succinyllysine desuccinylase activity	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in chromatin	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info	PubMed

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The following sections contain reference sequences that belong to a specific genome build. Explain