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    MOS MOS proto-oncogene, serine/threonine kinase [ Homo sapiens (human) ]

    Gene ID: 4342, updated on 27-Nov-2024

    Summary

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    Official Symbol
    MOSprovided by HGNC
    Official Full Name
    MOS proto-oncogene, serine/threonine kinaseprovided by HGNC
    Primary source
    HGNC:HGNC:7199
    See related
    Ensembl:ENSG00000172680 MIM:190060; AllianceGenome:HGNC:7199
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MSV; OZEMA20
    Summary
    MOS is a serine/threonine kinase that activates the MAP kinase cascade through direct phosphorylation of the MAP kinase activator MEK (MAP2K1; MIM 176872) (Prasad et al., 2008 [PubMed 18246541]).[supplied by OMIM, Jul 2009]
    Orthologs
    mouse all
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    Genomic context

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    See MOS in Genome Data Viewer
    Location:
    8q12.1
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (56112942..56113982, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (56489918..56490958, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (57025501..57026541, complement)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene competing endogenous lncRNA 3 for miR-645 Neighboring gene nucleophosmin 1 pseudogene 21 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:57025920-57026420 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:57030128-57030628 Neighboring gene uncharacterized LOC124900263 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:57054775-57055317 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19210 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr8:57079228-57080427 Neighboring gene PLAG1 zinc finger Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27399 Neighboring gene MPRA-validated peak7026 silencer Neighboring gene ReSE screen-validated silencer GRCh37_chr8:57124219-57124444

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Biallelic variants in MOS cause large polar body in oocyte and human female infertility. Zhang YL, et al. Hum Reprod, 2022 Jul 30. PMID 35670744
    2. Human proto-oncogene c-mos maps to 8q11. Caubet JF, et al. EMBO J, 1985 Sep. PMID 3000766, Free PMC Article
    3. Human DNA sequence homologous to the transforming gene (mos) of Moloney murine sarcoma virus. Watson R, et al. Proc Natl Acad Sci U S A, 1982 Jul. PMID 6287464, Free PMC Article
    4. Cell cycle genes c-mos and cyclin-B1 are expressed in a specific pattern in human oocytes and preimplantation embryos. Heikinheimo O, et al. Hum Reprod, 1995 Mar. PMID 7540181
    5. What does Mos do in oocytes and somatic cells? Sagata N. Bioessays, 1997 Jan. PMID 9008413

    See all (50) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MOS mutation causes female infertility with large polar body oocytes.
      Title: MOS mutation causes female infertility with large polar body oocytes.
    2. approach identified 18 kinase and kinase-related genes whose overexpression can substitute for EGFR in EGFR-dependent PC9 cells, and these genes include seven of nine Src family kinase genes, FGFR1, FGFR2, ITK, NTRK1, NTRK2, MOS, MST1R, and RAF1.
      Title: Genetic modifiers of EGFR dependence in non-small cell lung cancer.
    3. High methylation level in MOS is associated with intestinal metaplasia.
      Title: Changes in aberrant DNA methylation after Helicobacter pylori eradication: a long-term follow-up study.
    4. among the candidate genes, DNA methylation of MOS may reflect the duration of H. pylori exposure and may be a marker for the development of gastric cancer.
      Title: Prediction of the risk for gastric cancer using candidate methylation markers in the non-neoplastic gastric mucosae.
    5. Observational study of gene-disease association. (HuGE Navigator)
      Title: The role of height-associated loci identified in genome wide association studies in the determination of pediatric stature.
    6. In the absence of p53, Mos knockdown prevents multipolar mitoses and exerts genome-stabilizing effects.
      Title: Multipolar mitosis of tetraploid cells: inhibition by p53 and dependency on Mos.
    7. Cdc2 and Mos regulate Emi2 stability to promote the meiosis I-meiosis II transition
      Title: Cdc2 and Mos regulate Emi2 stability to promote the meiosis I-meiosis II transition.
    8. Mos 3' UTR regulatory differences underlie species-specific temporal patterns of Mos mRNA cytoplasmic polyadenylation and translational recruitment during oocyte maturation.
      Title: Mos 3' UTR regulatory differences underlie species-specific temporal patterns of Mos mRNA cytoplasmic polyadenylation and translational recruitment during oocyte maturation.
    9. These results clarify the direct link of the classical Mos-MAPK (mitogen-activated protein kinase) pathway to Erp1 in meiotic arrest of vertebrate oocytes.
      Title: A direct link of the Mos-MAPK pathway to Erp1/Emi2 in meiotic arrest of Xenopus laevis eggs.
    10. the Mos/MAPK pathway is not essential for initiating goldfish oocyte maturation despite its general function as a cytostatic factor (CSF).
      Title: The Mos/MAPK pathway is involved in metaphase II arrest as a cytostatic factor but is neither necessary nor sufficient for initiating oocyte maturation in goldfish.
    Submit: New GeneRIF Correction See all GeneRIFs (11)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Associated conditions

    Description Tests
    Oocyte/zygote/embryo maturation arrest 20
    MedGen: C5830539 OMIM: 620383 GeneReviews: Not available
    		not available

    EBI GWAS Catalog

    Description
    Many sequence variants affecting diversity of adult human height.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Replication interactions

    Interaction Pubs
    Knockdown of v-mos Moloney murine sarcoma viral oncogene homolog (MOS) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC119962, MGC119963

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables AMP-activated protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables MAP kinase kinase kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables Rho-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables eukaryotic translation initiation factor 2alpha kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS121 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AT120 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AXS139 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2BS14 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2BS36 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S10 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S28 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S57 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T11 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T3 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T45 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H4S1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables ribosomal protein S6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in MAPK cascade ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in chromatin organization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in establishment of meiotic spindle orientation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in meiotic spindle organization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of metaphase/anaphase transition of meiotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of metaphase/anaphase transition of meiotic cell cycle ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in oocyte maturation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of ERK1 and ERK2 cascade IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of MAPK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of MAPK cascade ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein autophosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of meiotic nuclear division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    proto-oncogene serine/threonine-protein kinase mos
    Names
    c-mos
    oncogene MOS, Moloney murine sarcoma virus
    oocyte maturation factor mos
    proto-oncogene c-Mos
    v-mos Moloney murine sarcoma viral oncogene homolog
    NP_005363.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_005372.1 → NP_005363.1  proto-oncogene serine/threonine-protein kinase mos

      See identical proteins and their annotated locations for NP_005363.1

      Status: VALIDATED

      Source sequence(s)
      AC107376
      Consensus CDS
      CCDS6164.1
      UniProtKB/Swiss-Prot
      P00540, Q3KPG9, Q3KPH0
      Related
      ENSP00000310722.1, ENST00000311923.1
      Conserved Domains (1) summary
      cd13979
      Location:56 → 338
      STKc_Mos; Catalytic domain of the Serine/Threonine kinase, Oocyte maturation factor Mos

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

      Range
      56112942..56113982 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060932.1 Alternate T2T-CHM13v2.0

      Range
      56489918..56490958 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P00540.1 GenPept UniProtKB/Swiss-Prot:P00540

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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