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    BOD1 Biorientation Defective 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43352, updated on 9-Dec-2024

    Summary

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    Official Symbol
    BOD1provided by FlyBase
    Official Full Name
    Biorientation Defective 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0039560
    Locus tag
    Dmel_CG5514
    See related
    AllianceGenome:FB:FBgn0039560
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Bod1; CG5514; Dmel\CG5514
    Summary
    Involved in nonassociative learning and synaptic assembly at neuromuscular junction. Predicted to be part of Set1C/COMPASS complex. Is expressed in embryonic/larval salivary gland and organism. Used to study intellectual disability. Orthologous to several human genes including BOD1 (biorientation of chromosomes in cell division 1) and BOD1L2 (biorientation of chromosomes in cell division 1 like 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See BOD1 in Genome Data Viewer
    Location:
    98B6-98B6; 3-94 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (27938245..27942778)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (23763967..23768500)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene minotaur Neighboring gene antisense RNA:CR46452 Neighboring gene Nuclear receptor binding SET domain protein Neighboring gene mitoferrin Neighboring gene Glycoprotein 93 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. BOD1 Is Required for Cognitive Function in Humans and Drosophila. Esmaeeli-Nieh S, et al. PLoS Genet, 2016 May. PMID 27166630, Free PMC Article
    2. Habituation in high-throughput genetic model organisms as a tool to investigate the mechanisms of neurodevelopmental disorders. Kepler LD, et al. Neurobiol Learn Mem, 2020 May. PMID 32147587
    3. Drosophila mitoferrin is essential for male fertility: evidence for a role of mitochondrial iron metabolism during spermatogenesis. Metzendorf C, et al. BMC Dev Biol, 2010 Jun 21. PMID 20565922, Free PMC Article
    4. Causal and Candidate Gene Variants in a Large Cohort of Women With Primary Ovarian Insufficiency. Gorsi B, et al. J Clin Endocrinol Metab, 2022 Feb 17. PMID 34718612, Free PMC Article
    5. Minotaur is critical for primary piRNA biogenesis. Vagin VV, et al. RNA, 2013 Aug. PMID 23788724, Free PMC Article

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in nonassociative learning IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in replication fork processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in synaptic assembly at neuromuscular junction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Set1C/COMPASS complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    biorientation defective 1
    Names
    BOD1-PA
    BOD1-PB
    BOD1-PC
    BOD1-PD
    BOD1-PE
    CG5514-PA
    CG5514-PB
    CG5514-PC
    CG5514-PD
    CG5514-PE

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      27938245..27942778
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_143342.2 → NP_651599.1  biorientation defective 1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651599.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IMM6
      Related
      FBpp0084622
      Conserved Domains (1) summary
      pfam05205
      Location:8 → 102
      COMPASS-Shg1; COMPASS (Complex proteins associated with Set1p) component shg1

    2. NM_001170280.2 → NP_001163751.1  biorientation defective 1, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163751.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VAY4
      Conserved Domains (1) summary
      pfam05205
      Location:8 → 102
      COMPASS-Shg1; COMPASS (Complex proteins associated with Set1p) component shg1

    3. NM_170361.3 → NP_733240.1  biorientation defective 1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_733240.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VAY4
      Related
      FBpp0084621
      Conserved Domains (1) summary
      pfam05205
      Location:8 → 102
      COMPASS-Shg1; COMPASS (Complex proteins associated with Set1p) component shg1

    4. NM_001276102.1 → NP_001263031.1  biorientation defective 1, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001263031.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KHZ9
      Conserved Domains (1) summary
      pfam05205
      Location:8 → 102
      COMPASS-Shg1; COMPASS (Complex proteins associated with Set1p) component shg1

    5. NM_001276101.1 → NP_001263030.1  biorientation defective 1, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001263030.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IMM6
      Conserved Domains (1) summary
      pfam05205
      Location:8 → 102
      COMPASS-Shg1; COMPASS (Complex proteins associated with Set1p) component shg1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KHZ9 A0A0B4KHZ9
    Q8IMM6 Q8IMM6
    Q8MRP6 Q8MRP6
    Q9VAY4 Q9VAY4

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