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    Cow Carrier of Wingless [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42733, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cowprovided by FlyBase
    Official Full Name
    Carrier of Winglessprovided by FlyBase
    Primary source
    FLYBASE:FBgn0039054
    Locus tag
    Dmel_CG13830
    See related
    AllianceGenome:FB:FBgn0039054
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG13830; cow; Dmel\CG13830
    Summary
    Enables Wnt-protein binding activity. Involved in several processes, including extracellular transport; regionalization; and regulation of canonical Wnt signaling pathway. Located in extracellular space. Is expressed in several structures, including adult head; imaginal disc; larval ventral nerve cord; and spermatozoon. Human ortholog(s) of this gene implicated in hepatocellular carcinoma. Orthologous to human SPOCK1 (SPARC (osteonectin), cwcv and kazal like domains proteoglycan 1); SPOCK2 (SPARC (osteonectin), cwcv and kazal like domains proteoglycan 2); and SPOCK3 (SPARC (osteonectin), cwcv and kazal like domains proteoglycan 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Cow in Genome Data Viewer
    Location:
    94D12-94D13; 3-77 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (23070516..23112730, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (18896238..18938452, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Cystinosin Neighboring gene Ubiquitin-like domain-containing C-terminal domain phosphatase 1 Neighboring gene salvador Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Ras association family member Neighboring gene Centaurin beta 1A Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Carrier of Wingless (Cow) Regulation of Drosophila Neuromuscular Junction Development. Kopke DL, et al. eNeuro, 2020 Mar/Apr. PMID 32024666, Free PMC Article
    2. Genetic Architecture of Natural Variation Underlying Adult Foraging Behavior That Is Essential for Survival of Drosophila melanogaster. Lee YCG, et al. Genome Biol Evol, 2017 May 1. PMID 28472322, Free PMC Article
    3. Carrier of Wingless (Cow), a secreted heparan sulfate proteoglycan, promotes extracellular transport of Wingless. Chang YH, et al. PLoS One, 2014. PMID 25360738, Free PMC Article
    4. Regulation of Wnt distribution and function by Drosophila glypicans. Waghmare I, et al. J Cell Sci, 2022 Feb 1. PMID 35112708, Free PMC Article
    5. Loss of the extracellular matrix protein Perlecan disrupts axonal and synaptic stability during Drosophila development. Guss EJ, et al. Elife, 2023 Jun 27. PMID 37368474, Free PMC Article

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Carrier of Wingless (Cow) Regulation of Drosophila Neuromuscular Junction Development.
      Title: Carrier of Wingless (Cow) Regulation of Drosophila Neuromuscular Junction Development.
    2. Cow promotes the apical transport of Wg, independent of Dlp and endocytosis.
      Title: Carrier of Wingless (Cow), a secreted heparan sulfate proteoglycan, promotes extracellular transport of Wingless.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables Wnt-protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in establishment of protein localization to extracellular region IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in establishment of protein localization to extracellular region IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in extracellular transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of canonical Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of canonical Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in segment polarity determination IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in wing disc dorsal/ventral pattern formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    carrier of wingless
    Names
    CG13830-PC
    CG13830-PD
    CG13830-PE
    Cow-PC
    Cow-PD
    Cow-PE

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      23070516..23112730 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001104413.3 → NP_001097883.2  carrier of wingless, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097883.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B5RJH8, Q9VCR3
      Conserved Domains (4) summary
      smart00280
      Location:240 → 272
      KAZAL; Kazal type serine protease inhibitors
      cd00191
      Location:535 → 594
      TY; Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases
      cd00252
      Location:427 → 539
      SPARC_EC; SPARC_EC; extracellular Ca2+ binding domain (containing 2 EF-hand motifs) of SPARC and related proteins (QR1, SC1/hevin, testican and tsc-36/FRP). SPARC (BM-40) is a multifunctional glycoprotein, a matricellular protein, that functions to regulate ...
      pfam10591
      Location:427 → 526
      SPARC_Ca_bdg; Secreted protein acidic and rich in cysteine Ca binding region

    2. NM_001170224.2 → NP_001163695.1  carrier of wingless, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163695.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B5RJH8, Q9VCR3
      Conserved Domains (4) summary
      smart00280
      Location:240 → 272
      KAZAL; Kazal type serine protease inhibitors
      cd00191
      Location:535 → 594
      TY; Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases
      cd00252
      Location:427 → 539
      SPARC_EC; SPARC_EC; extracellular Ca2+ binding domain (containing 2 EF-hand motifs) of SPARC and related proteins (QR1, SC1/hevin, testican and tsc-36/FRP). SPARC (BM-40) is a multifunctional glycoprotein, a matricellular protein, that functions to regulate ...
      pfam10591
      Location:427 → 526
      SPARC_Ca_bdg; Secreted protein acidic and rich in cysteine Ca binding region

    3. NM_001275928.1 → NP_001262857.1  carrier of wingless, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262857.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KH80
      Conserved Domains (4) summary
      smart00280
      Location:240 → 272
      KAZAL; Kazal type serine protease inhibitors
      cd00191
      Location:535 → 597
      TY; Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases
      cd00252
      Location:427 → 539
      SPARC_EC; SPARC_EC; extracellular Ca2+ binding domain (containing 2 EF-hand motifs) of SPARC and related proteins (QR1, SC1/hevin, testican and tsc-36/FRP). SPARC (BM-40) is a multifunctional glycoprotein, a matricellular protein, that functions to regulate ...
      pfam10591
      Location:427 → 526
      SPARC_Ca_bdg; Secreted protein acidic and rich in cysteine Ca binding region
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KH80 A0A0B4KH80
    Q9VCR3.3 Q9VCR3

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