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    Nepl14 Neprilysin-like 14 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42700, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Nepl14provided by FlyBase
    Official Full Name
    Neprilysin-like 14provided by FlyBase
    Primary source
    FLYBASE:FBgn0039023
    Locus tag
    Dmel_CG4723
    See related
    AllianceGenome:FB:FBgn0039023
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG4723; Dmel\CG4723
    Summary
    Predicted to be involved in proteolysis. Predicted to be active in plasma membrane. Is expressed in embryonic brain; larval ventral nerve cord; and organism. Human ortholog(s) of this gene implicated in distal arthrogryposis type 5D. Orthologous to human ECEL1 (endothelin converting enzyme like 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Nepl14 in Genome Data Viewer
    Location:
    94C4-94C4; 3-76 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (22761440..22763711, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (18587162..18589433, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Ubiquitin-specific protease 12/46 Neighboring gene rumi Neighboring gene uncharacterized protein Neighboring gene Neprilysin-like 13 Neighboring gene Neprilysin-like 15 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A timely expression profile. Jackson FR, et al. Dev Cell, 2001 Dec. PMID 11740934
    2. Identification and bioinformatic analysis of neprilysin and neprilysin-like metalloendopeptidases in Drosophila melanogaster. Meyer H, et al. MicroPubl Biol, 2021 Jun 23. PMID 34189422, Free PMC Article
    3. Genome-wide view of cell fate specification: ladybird acts at multiple levels during diversification of muscle and heart precursors. Junion G, et al. Genes Dev, 2007 Dec 1. PMID 18056427, Free PMC Article
    4. Circadian regulation of gene expression systems in the Drosophila head. Claridge-Chang A, et al. Neuron, 2001 Nov 20. PMID 11719206
    5. Transcriptomic analysis of inbreeding depression in cold-sensitive Drosophila melanogaster shows upregulation of the immune response. Vermeulen CJ, et al. J Evol Biol, 2013 Sep. PMID 23944235

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    NOT enables peptidase activity IKR
    Inferred from Key Residues
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Neprilysin-like 14
    Names
    CG4723-PA
    Nepl14-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      22761440..22763711 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_142840.4 → NP_651097.1  Neprilysin-like 14 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651097.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VCU2
      Related
      FBpp0083711
      Conserved Domains (1) summary
      cd08662
      Location:60 → 693
      M13; Peptidase family M13 includes neprilysin, endothelin-converting enzyme I
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VCU2 Q9VCU2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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