wake wide awake [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: wakeprovided by FlyBase
Official Full Name: wide awakeprovided by FlyBase
Primary source: FLYBASE:FBgn0266418
Locus tag: Dmel_CG45058
See related: AllianceGenome:FB:FBgn0266418
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: ban; CG17622; CG17623; CG42686; CG45058; CG6954; Dmel\CG45058; WAKE; Wide awake
Old locus tag: Dmel_CG17622; Dmel_CG17623; Dmel_CG42686; Dmel_CG6954
Summary: Enables GABA receptor binding activity. Involved in several processes, including asymmetric neuroblast division; establishment of mitotic spindle orientation; and positive regulation of circadian sleep/wake cycle, sleep. Located in centrosome and spindle. Is expressed in several structures, including adult head; adult pacemaker neurons; brain; dorsal ectoderm; and hindgut anlage. Orthologous to human ANKFN1 (ankyrin repeat and fibronectin type III domain containing 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 94B8-94C1; 3-75 cM

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (22639808..22683827)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (18465530..18509549)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

homozygotes for null mutations in the Drosophila homolog of Nmf9, CG45058, show profound locomotor defects and premature death, while heterozygotes show striking effects on sleep and activity phenotypes.
Title: Nmf9 Encodes a Highly Conserved Protein Important to Neurological Function in Mice and Flies.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables GABA receptor binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in asymmetric neuroblast division	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in asymmetric stem cell division	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment of mitotic spindle orientation	IBA Inferred from Biological aspect of Ancestor more info
involved_in establishment of mitotic spindle orientation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of circadian sleep/wake cycle, sleep	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of establishment of bipolar cell polarity	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of establishment of bipolar cell polarity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in centrosome	IDA Inferred from Direct Assay more info	PubMed
is_active_in spindle	IBA Inferred from Biological aspect of Ancestor more info
located_in spindle	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: wide awake

Names: CG45058-PB; CG45058-PC; CG45058-PD; CG45058-PE; CG45058-PF; CG45058-PG; CG45058-PH; banderuola; wake-PB; wake-PC; wake-PD; wake-PE; wake-PF; wake-PG; wake-PH

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

22639808..22683827

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001300541.1 → NP_001287470.1 wide awake, isoform H [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001287470.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4LHH4, D0Z761

Conserved Domains (5) summary

cd00063
Location:406 → 503

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd00204
Location:251 → 313

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam13637
Location:255 → 309

Ank_4; Ankyrin repeats (many copies)

sd00045
Location:258 → 286

ANK; ANK repeat [structural motif]

cl00155
Location:1288 → 1386

UBQ; Ubiquitin-like proteins
NM_001300540.1 → NP_001287469.1 wide awake, isoform G [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001287469.1

Status: REVIEWED

UniProtKB/TrEMBL

X4YX01

Conserved Domains (5) summary

cd00063
Location:651 → 748

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd00204
Location:502 → 558

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam13637
Location:502 → 554

Ank_4; Ankyrin repeats (many copies)

sd00045
Location:503 → 531

ANK; ANK repeat [structural motif]

cl00155
Location:1533 → 1631

UBQ; Ubiquitin-like proteins
NM_001260316.1 → NP_001247245.1 wide awake, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001247245.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4K6D0, D0Z761

Conserved Domains (5) summary

cd00063
Location:420 → 517

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd00204
Location:261 → 327

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam13637
Location:269 → 323

Ank_4; Ankyrin repeats (many copies)

sd00045
Location:272 → 300

ANK; ANK repeat [structural motif]

cl00155
Location:1302 → 1400

UBQ; Ubiquitin-like proteins
NM_142819.3 → NP_651076.2 wide awake, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_651076.2

Status: REVIEWED

UniProtKB/TrEMBL

D0Z761, Q9VCW7

Conserved Domains (5) summary

cd00063
Location:258 → 355

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd00204
Location:99 → 165

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam13637
Location:107 → 161

Ank_4; Ankyrin repeats (many copies)

sd00045
Location:110 → 138

ANK; ANK repeat [structural motif]

cl00155
Location:1140 → 1238

UBQ; Ubiquitin-like proteins
NM_001260315.1 → NP_001247244.1 wide awake, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001247244.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4K6D0, D0Z761

Conserved Domains (5) summary

cd00063
Location:420 → 517

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd00204
Location:261 → 327

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam13637
Location:269 → 323

Ank_4; Ankyrin repeats (many copies)

sd00045
Location:272 → 300

ANK; ANK repeat [structural motif]

cl00155
Location:1302 → 1400

UBQ; Ubiquitin-like proteins
NM_001202337.2 → NP_001189266.1 wide awake, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001189266.1

Status: REVIEWED

UniProtKB/TrEMBL

D0Z761, Q9VCW7

Conserved Domains (5) summary

cd00063
Location:258 → 355

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd00204
Location:99 → 165

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam13637
Location:107 → 161

Ank_4; Ankyrin repeats (many copies)

sd00045
Location:110 → 138

ANK; ANK repeat [structural motif]

cl00155
Location:1140 → 1238

UBQ; Ubiquitin-like proteins
NM_001260314.3 → NP_001247243.1 wide awake, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001247243.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4K6W6, D0Z761

Conserved Domains (5) summary

cd00063
Location:556 → 653

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd00204
Location:397 → 463

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam13637
Location:405 → 459

Ank_4; Ankyrin repeats (many copies)

sd00045
Location:408 → 436

ANK; ANK repeat [structural motif]

cl00155
Location:1438 → 1536

UBQ; Ubiquitin-like proteins