CSN6 COP9 signalosome subunit 6 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: CSN6provided by FlyBase
Official Full Name: COP9 signalosome subunit 6provided by FlyBase
Primary source: FLYBASE:FBgn0028837
Locus tag: Dmel_CG6932
See related: AllianceGenome:FB:FBgn0028837
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG6932; CH6; csn6; Csn6; Dch6; Dmel\CG6932; Q9VCY3
Summary: Involved in several processes, including female germ-line stem cell population maintenance; male germ-line cyst encapsulation; and protein stabilization. Predicted to be part of COP9 signalosome. Is expressed in several structures, including adult head; anterior endoderm; anterior endoderm anlage; anterior midgut primordium; and mesoderm. Orthologous to human COPS6 (COP9 signalosome subunit 6). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (22580773..22582033)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (18406495..18407755)

Chromosome 3R - NT_033777.3

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

the 2.5A crystal structure of MPN domain from Drosophila melanogaster CSN6.
Title: The crystal structure of the MPN domain from the COP9 signalosome subunit CSN6.

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
NOT enables metal-dependent deubiquitinase activity	ISS Inferred from Sequence or Structural Similarity more info
NOT enables metallopeptidase activity	IKR Inferred from Key Residues more info	PubMed
NOT enables peptidase activity	IKR Inferred from Key Residues more info	PubMed
NOT enables peptidase activity	ISS Inferred from Sequence or Structural Similarity more info
NOT enables zinc ion binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in female germ-line stem cell population maintenance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in germ cell development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in male germ-line cyst encapsulation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein deneddylation	IEA Inferred from Electronic Annotation more info
involved_in protein deneddylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein stabilization	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of COP9 signalosome	IBA Inferred from Biological aspect of Ancestor more info
part_of COP9 signalosome	IEA Inferred from Electronic Annotation more info
part_of COP9 signalosome	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Names: CG6932-PA; COP9 complex homolog subunit 6; CSN6-PA; drosophila COP9 signalosome homolog 6

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The following sections contain reference sequences that belong to a specific genome build. Explain