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    Sec15 Secretory 15 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42499, updated on 17-Dec-2024

    Summary

    Official Symbol
    Sec15provided by FlyBase
    Official Full Name
    Secretory 15provided by FlyBase
    Primary source
    FLYBASE:FBgn0266674
    Locus tag
    Dmel_CG7034
    See related
    AllianceGenome:FB:FBgn0266674
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    3R41; CG7034; Dmel\CG7034; dsec15; sec15; Sec15p
    Summary
    Enables small GTPase binding activity. Involved in several processes, including border follicle cell migration; endocytic recycling; and phototaxis. Located in axon terminus and recycling endosome. Part of exocyst. Is expressed in adult head; lamina; and ommatidial precursor cluster. Human ortholog(s) of this gene implicated in spondyloepimetaphyseal dysplasia with joint laxity type 3. Orthologous to several human genes including EXOC6B (exocyst complex component 6B). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See Sec15 in Genome Data Viewer
    Location:
    93B12-93B12; 3-70 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (21105046..21107972, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (16930768..16933694, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR46045 Neighboring gene TBC1 domain family member 22 Neighboring gene tetracycline resistance Neighboring gene Rab11

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by FlyBase

    Component Evidence Code Pubs
    located_in axon terminus PubMed 
    located_in cytoplasmic vesicle PubMed 
    located_in endosome PubMed 
    part_of exocyst  
    part_of exocyst PubMed 
    located_in recycling endosome PubMed 

    General protein information

    Preferred Names
    secretory 15
    Names
    CG7034-PA
    Sec15 ortholog
    Sec15-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      21105046..21107972 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_142685.3 → NP_650942.1  secretory 15 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650942.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q53YF7, Q9VDE6
      Related
      FBpp0083436
      Conserved Domains (1) summary
      pfam04091
      Location:428 → 730
      Sec15; Exocyst complex subunit Sec15-like
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