Sirt2 Sirtuin 2 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Sirt2provided by FlyBase
Official Full Name: Sirtuin 2provided by FlyBase
Primary source: FLYBASE:FBgn0038788
Locus tag: Dmel_CG5085
See related: AllianceGenome:FB:FBgn0038788
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG5085; D.mel2; Dmel\CG5085; DmSir2; dsirt2; dSIRT2; Sir2; sirt2; SIRT2
Summary: Enables NAD-dependent histone deacetylase activity. Involved in determination of adult lifespan and response to starvation. Is active in nucleus. Is expressed in several structures, including embryonic large intestine; embryonic/larval midgut primordium; gut section; larval muscle system; and somatic muscle primordium. Orthologous to human SIRT2 (sirtuin 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 92E3-92E3; 3-68 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (20328465..20330915)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (16154187..16156637)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Knockdown of SIRT2 Rescues YARS-induced Charcot-Marie-Tooth Neuropathy in Drosophila.
Title: Knockdown of SIRT2 Rescues YARS-induced Charcot-Marie-Tooth Neuropathy in Drosophila.
Sirt2 has an role in the regulation of mitochondrial energy metabolism.
Title: Drosophila Sirt2/mammalian SIRT3 deacetylates ATP synthase β and regulates complex V activity.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables NAD+ binding	IBA Inferred from Biological aspect of Ancestor more info
enables NAD+ binding	IEA Inferred from Electronic Annotation more info
enables histone deacetylase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables histone deacetylase activity, NAD-dependent	IBA Inferred from Biological aspect of Ancestor more info
enables histone deacetylase activity, NAD-dependent	IDA Inferred from Direct Assay more info	PubMed
enables histone deacetylase activity, NAD-dependent	IEA Inferred from Electronic Annotation more info
enables histone deacetylase activity, NAD-dependent	NAS Non-traceable Author Statement more info	PubMed
enables protein lysine deacetylase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in determination of adult lifespan	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in rDNA heterochromatin formation	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to starvation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info	PubMed

General protein information

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Preferred Names: sirtuin 2

Names: CG5085-PC; CG5085-PD; Sirt2-PC; Sirt2-PD; drosophila sirtuin 2; sirtuin

NP_001287422.2

EC 3.5.1.98

NP_650880.3

EC 3.5.1.98

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

20328465..20330915

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001300493.1 → NP_001287422.2 sirtuin 2, isoform D [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9I7I7

UniProtKB/TrEMBL

A0A0B4LHF9, R4HZM7

Conserved Domains (1) summary

cd01408
Location:79 → 330

SIRT1; Eukaryotic group (class1) which includes human sirtuins SIRT1-3 and yeast Hst1-4; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 proteins ...
NM_142623.4 → NP_650880.3 sirtuin 2, isoform C [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9I7I7

UniProtKB/TrEMBL

A0A0B4LHF9, R4HZM7

Conserved Domains (1) summary

cd01408
Location:79 → 330

SIRT1; Eukaryotic group (class1) which includes human sirtuins SIRT1-3 and yeast Hst1-4; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 proteins ...