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    Xrp1 Xrp1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42267, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Xrp1provided by FlyBase
    Official Full Name
    Xrp1provided by FlyBase
    Primary source
    FLYBASE:FBgn0261113
    Locus tag
    Dmel_CG17836
    See related
    AllianceGenome:FB:FBgn0261113
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    2515; anon-EST:Liang-2.44; CG17836; clone 2.44; DM28; Dmel\CG17836; l(3)02515; Xrp; xrp1; XRP1
    Summary
    Enables P-element binding activity and chromatin binding activity. Involved in chromosome organization; double-strand break repair; and negative regulation of cell population proliferation. Located in nucleus. Part of DNA repair complex. Is expressed in several structures, including anal pad primordium; dorsal epidermis primordium; embryonic anal pad; embryonic dorsal epidermis; and embryonic head epidermis. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

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    See Xrp1 in Genome Data Viewer
    Location:
    91D4-91D5; 3-65 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (18914968..18926989)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (14740690..14752711)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Endophilin A Neighboring gene N-sulfoglucosamine sulfohydrolase Neighboring gene uncharacterized protein Neighboring gene Mitochondrial pyruvate carrier Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Drosophila IRBP bZIP heterodimer binds P-element DNA and affects hybrid dysgenesis. Francis MJ, et al. Proc Natl Acad Sci U S A, 2016 Nov 15. PMID 27799520, Free PMC Article
    2. Whole-Genome Sequencing and iPLEX MassARRAY Genotyping Map an EMS-Induced Mutation Affecting Cell Competition in Drosophila melanogaster. Lee CH, et al. G3 (Bethesda), 2016 Oct 13. PMID 27574103, Free PMC Article
    3. Cell competition is driven by Xrp1-mediated phosphorylation of eukaryotic initiation factor 2α. Ochi N, et al. PLoS Genet, 2021 Dec. PMID 34871307, Free PMC Article
    4. Reducing the aneuploid cell burden - cell competition and the ribosome connection. Baker NE, et al. Dis Model Mech, 2022 Nov 1. PMID 36444717, Free PMC Article
    5. A potential link between p53, cell competition and ribosomopathy in mammals and in Drosophila. Baker NE, et al. Dev Biol, 2019 Feb 1. PMID 30513308, Free PMC Article

    See all (99) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Xrp1 governs the stress response program to spliceosome dysfunction.
      Title: Xrp1 governs the stress response program to spliceosome dysfunction.
    2. Xrp1 and Irbp18 trigger a feed-forward loop of proteotoxic stress to induce the loser status.
      Title: Xrp1 and Irbp18 trigger a feed-forward loop of proteotoxic stress to induce the loser status.
    3. Cell competition is driven by Xrp1-mediated phosphorylation of eukaryotic initiation factor 2alpha.
      Title: Cell competition is driven by Xrp1-mediated phosphorylation of eukaryotic initiation factor 2α.
    4. The transcription factor Xrp1 is required for PERK-mediated antioxidant gene induction in Drosophila.
      Title: The transcription factor Xrp1 is required for PERK-mediated antioxidant gene induction in Drosophila.
    5. Roles of C/EBP class bZip proteins in the growth and cell competition of Rp ('Minute') mutants in Drosophila.
      Title: Roles of C/EBP class bZip proteins in the growth and cell competition of Rp ('Minute') mutants in Drosophila.
    6. Findings provide clear molecular and genetic evidence that RpS12 plays a central and early role in generating multiple aspects of the Ribosomal Protein (Rp)+/- phenotype in imaginal discs by activating Xrp1 expression and activity.
      Title: Drosophila RpS12 controls translation, growth, and cell competition through Xrp1.
    7. demonstrates that RpS12, Xrp1, and Dilp8 form an independent regulatory module that ensures intra- and inter-organ growth coordination during development
      Title: Inter-Organ Growth Coordination Is Mediated by the Xrp1-Dilp8 Axis in Drosophila.
    8. Xrp1 knockdown substantially rescued the motor deficits and life span of flies expressing ALS mutant FUS in motor neurons, implicating gene expression dysregulation in ALS-FUS pathogenesis.
      Title: Xrp1 genetically interacts with the ALS-associated FUS orthologue caz and mediates its toxicity.
    9. Xrp1 induction in Rp mutant cells depends on a particular Rp with regulatory effects
      Title: A Regulatory Response to Ribosomal Protein Mutations Controls Translation, Growth, and Cell Competition.
    10. CG17836/Xrp1 is involved in the regulation of cell proliferation in eye discs and affects disc identity specification.
      Title: Ectopic antenna induction by overexpression of CG17836/Xrp1 encoding an AT-hook DNA binding motif protein in Drosophila.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    mobile_element

    • Loc: 18917445-18917825 mobile_element_type = transposon:S2{}1385
    • Loc: 18922054-18922275 mobile_element_type = transposon:1360{}4814

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables P-element binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chromosome organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in double-strand break repair IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of DNA repair complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Xrp1
    Names
    CG17836-PA
    CG17836-PB
    CG17836-PC
    CG17836-PD
    CG17836-PE
    CG17836-PF
    CG17836-PG
    Xrp1-PA
    Xrp1-PB
    Xrp1-PC
    Xrp1-PD
    Xrp1-PE
    Xrp1-PF
    Xrp1-PG
    lethal (3) 02515

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      18914968..18926989
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_142504.4 → NP_650761.2  Xrp1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650761.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VE23
      Related
      FBpp0083114
      Conserved Domains (1) summary
      cd14686
      Location:599 → 640
      bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain

    2. NM_001275790.1 → NP_001262719.1  Xrp1, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262719.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VE23
      Conserved Domains (1) summary
      cd14686
      Location:599 → 640
      bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain

    3. NM_169839.3 → NP_732384.1  Xrp1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_732384.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VE23
      Related
      FBpp0083115
      Conserved Domains (1) summary
      cd14686
      Location:599 → 640
      bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain

    4. NM_169840.3 → NP_732385.1  Xrp1, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_732385.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8I0S0, Q8IN74
      Related
      FBpp0083116
      Conserved Domains (1) summary
      cd14686
      Location:337 → 378
      bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain

    5. NM_001104363.2 → NP_001097833.1  Xrp1, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097833.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8I0S0, Q8IN74
      Conserved Domains (1) summary
      cd14686
      Location:337 → 378
      bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain

    6. NM_001275789.1 → NP_001262718.1  Xrp1, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262718.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VE23
      Conserved Domains (1) summary
      cd14686
      Location:599 → 640
      bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain

    7. NM_169841.2 → NP_732386.1  Xrp1, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_732386.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8I0S0, Q8IN74
      Related
      FBpp0083117
      Conserved Domains (1) summary
      cd14686
      Location:337 → 378
      bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8I0S0 Q8I0S0
    Q8IN74 Q8IN74
    Q8T9G5 Q8T9G5
    Q9VE23 Q9VE23

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