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    Mps1 Monopolar spindle 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42126, updated on 17-Dec-2024

    Summary

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    Official Symbol
    Mps1provided by FlyBase
    Official Full Name
    Monopolar spindle 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0000063
    Locus tag
    Dmel_CG7643
    See related
    AllianceGenome:FB:FBgn0000063
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    ald; Ald; Ald/Mps1; CG7643; Dmel\CG7643; dMps1; mps1; Msp1; TKK
    Summary
    Enables protein serine/threonine/tyrosine kinase activity. Involved in several processes, including male germ-line stem cell asymmetric division; meiotic nuclear division; and negative regulation of metaphase/anaphase transition of cell cycle. Located in centrosome and kinetochore. Part of outer kinetochore. Is expressed in several structures, including central brain primordium; ganglia; oocyte; and ventral nerve cord primordium. Orthologous to human TTK (TTK protein kinase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

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    See Mps1 in Genome Data Viewer
    Location:
    90C1-90C1; 3-61 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (17671271..17673828)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (13496993..13499550)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene transfer RNA:Alanine-AGC 2-10 Neighboring gene uncharacterized protein Neighboring gene aluminum tubes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Meiotic chromosome behavior influenced by mutation-altered disjunction in Drosophila melanogaster females. O'Tousa J. Genetics, 1982 Nov. PMID 6816677, Free PMC Article
    2. Nondisjunctional segregations in Drosophila female meiosis I are preceded by homolog malorientation at metaphase arrest. Gillies SC, et al. Genetics, 2013 Feb. PMID 23222652, Free PMC Article
    3. Requiem for distributive segregation: achiasmate segregation in Drosophila females. Hawley RS, et al. Trends Genet, 1993 Sep. PMID 8236460
    4. Direct evidence of a role for heterochromatin in meiotic chromosome segregation. Dernburg AF, et al. Cell, 1996 Jul 12. PMID 8689681
    5. Spindle regulation: Mps1 flies into new areas. Fisk HA, et al. Curr Biol, 2004 Dec 29. PMID 15620641

    See all (74) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Mps1-mediated release of Mad1 from nuclear pores ensures the fidelity of chromosome segregation.
      Title: Mps1-mediated release of Mad1 from nuclear pores ensures the fidelity of chromosome segregation.
    2. Here the authors show in vitro and in Drosophila that Protein Phosphatase 1 (PP1) inactivates Mps1 by dephosphorylating its T-loop. PP1-mediated dephosphorylation of Mps1 occurs at kinetochores and in the cytosol, and inactivation of both pools of Mps1 during metaphase is essential to ensure prompt and efficient Spindle Assembly Checkpoint silencing.
      Title: Protein Phosphatase 1 inactivates Mps1 to ensure efficient Spindle Assembly Checkpoint silencing.
    3. a model in which Polo controls Mps1-dependent BubR1 phosphorylation to promote Cdc20 kinetochore recruitment and sustained SAC function.
      Title: Drosophila Polo regulates the spindle assembly checkpoint through Mps1-dependent BubR1 phosphorylation.
    4. Kinetochore localized Mad2 and Cdc20 is itself insufficient for triggering the mitotic checkpoint when Mps1 is low in Drosophila melanogaster neuroblasts.
      Title: Kinetochore localized Mad2 and Cdc20 is itself insufficient for triggering the mitotic checkpoint when Mps1 is low in Drosophila melanogaster neuroblasts.
    5. Data indicate kinase activity seems to be required for Mps1 kinetochore localization.
      Title: Spindle checkpoint-independent inhibition of mitotic chromosome segregation by Drosophila Mps1.
    6. mps1 and polo are sequestered to collagenase-sensitive filaments in Drosophila prometaphase oocytes under hypoxic conditions
      Title: Hypoxia transiently sequesters mps1 and polo to collagenase-sensitive filaments in Drosophila prometaphase oocytes.
    7. oocytes lacking Ald/Mps1 protein enter anaphase I immediately upon completing spindle formation, in a fashion that does not allow sufficient time for nonexchange homologs to complete their normal partitioning to opposite half spindles
      Title: The multiple roles of mps1 in Drosophila female meiosis.
    8. Mps1 is required for the arrest of cell cycle progression in response to hypoxia
      Title: The mitotic arrest in response to hypoxia and of polar bodies during early embryogenesis requires Drosophila Mps1.
    9. Mps1 plays an important role in Drosophila female meiosis by regulating processes that are especially critical for ensuring the proper segregation of nonexchange chromosomes.
      Title: The meiotic defects of mutants in the Drosophila mps1 gene reveal a critical role of Mps1 in the segregation of achiasmate homologs.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine/tyrosine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine/tyrosine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in achiasmate meiosis I IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chromosome segregation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in distributive segregation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in distributive segregation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in female meiosis chromosome segregation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in female meiotic nuclear division IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in male germ-line stem cell asymmetric division IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in meiotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in meiotic metaphase I homologous chromosome alignment IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in meiotic spindle assembly checkpoint signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in meiotic spindle assembly checkpoint signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in meiotic spindle checkpoint signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic spindle assembly checkpoint signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic spindle assembly checkpoint signaling IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in mitotic spindle assembly checkpoint signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of sister chromatid segregation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of protein localization to kinetochore IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein localization to kinetochore IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to hypoxia IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in kinetochore IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in kinetochore IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of outer kinetochore IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    monopolar spindle 1
    Names
    CG7643-PA
    CG7643-PB
    Mps1-PA
    Mps1-PB
    altered disjunction
    monopolar spindles 1
    NP_001262677.1
    NP_650644.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      17671271..17673828
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001275748.1 → NP_001262677.1  monopolar spindle 1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262677.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KG66
      Conserved Domains (2) summary
      smart00220
      Location:337 → 575
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14131
      Location:335 → 579
      PKc_Mps1; Catalytic domain of the Dual-specificity Mitotic checkpoint protein kinase, Monopolar spindle 1 (also called TTK)

    2. NM_142387.3 → NP_650644.1  monopolar spindle 1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650644.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VEH1
      Related
      FBpp0082911
      Conserved Domains (2) summary
      smart00220
      Location:337 → 611
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14131
      Location:335 → 612
      PKc_Mps1; Catalytic domain of the Dual-specificity Mitotic checkpoint protein kinase, Monopolar spindle 1 (also called TTK)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KG66 A0A0B4KG66
    Q9VEH1 Q9VEH1

    Gene LinkOut

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