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    CG12951 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41110, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG12951provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0037677
    Locus tag
    Dmel_CG12951
    See related
    AllianceGenome:FB:FBgn0037677
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG12951; SP87
    Summary
    Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Orthologous to human KLK14 (kallikrein related peptidase 14). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG12951 in Genome Data Viewer
    Location:
    85D11-85D11; 3-48 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (9329223..9330331, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (5154945..5156053, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR46350 Neighboring gene uncharacterized protein Neighboring gene Heterochromatin Protein 1e Neighboring gene uncharacterized protein Neighboring gene Another Drosophila Unc-51-like kinase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Drosophila Regnase-1 RNase is required for mRNA and miRNA profile remodelling during larva-to-adult metamorphosis. Zhu L, et al. RNA Biol, 2019 Oct. PMID 31195914, Free PMC Article
    2. Population- and sex-biased gene expression in the excretion organs of Drosophila melanogaster. Huylmans AK, et al. G3 (Bethesda), 2014 Sep 22. PMID 25246242, Free PMC Article
    3. Meta-Analysis of Grainyhead-Like Dependent Transcriptional Networks: A Roadmap for Identifying Novel Conserved Genetic Pathways. Mathiyalagan N, et al. Genes (Basel), 2019 Oct 31. PMID 31683705, Free PMC Article
    4. SAGA-mediated H2B deubiquitination controls the development of neuronal connectivity in the Drosophila visual system. Weake VM, et al. EMBO J, 2008 Jan 23. PMID 18188155, Free PMC Article
    5. Infection Dynamics and Immune Response in a Newly Described Drosophila-Trypanosomatid Association. Hamilton PT, et al. mBio, 2015 Sep 15. PMID 26374124, Free PMC Article

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables serine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine-type endopeptidase activity ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteolysis ISM
    Inferred from Sequence Model
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG12951-PA
    NP_649880.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      9329223..9330331 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_141623.2 → NP_649880.1  uncharacterized protein Dmel_CG12951 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649880.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D9PTT1, Q9VHF8
      Related
      FBpp0081536
      Conserved Domains (2) summary
      smart00020
      Location:29 → 257
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:30 → 260
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VHF8 Q9VHF8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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