U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    galcb galactosylceramidase b [ Danio rerio (zebrafish) ]

    Gene ID: 406385, updated on 9-Dec-2024

    Summary

    Official Symbol
    galcbprovided by ZNC
    Official Full Name
    galactosylceramidase bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-2115
    See related
    Ensembl:ENSDARG00000016474 AllianceGenome:ZFIN:ZDB-GENE-040426-2115
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    galc; zgc:56444; wu:fi04e07
    Summary
    Enables galactosylceramidase activity. Predicted to be involved in galactosylceramide catabolic process. Predicted to act upstream of or within lipid catabolic process and sphingolipid metabolic process. Located in lysosome. Is expressed in melanoblast and nervous system. Used to study melanoma. Human ortholog(s) of this gene implicated in Krabbe disease. Orthologous to human GALC (galactosylceramidase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See galcb in Genome Data Viewer
    Location:
    chromosome: 17
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 17 NC_007128.7 (18889126..18898082, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 17 NC_007128.6 (18869801..18878246, complement)

    Chromosome 17 - NC_007128.7Genomic Context describing neighboring genes Neighboring gene si:dkey-288a3.2 Neighboring gene adenylate kinase 7b Neighboring gene si:dkey-87k14.1 Neighboring gene uncharacterized LOC137488090

    Genomic regions, transcripts, and products

    Expression

    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    General gene information

    Markers

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables galactosylceramidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables galactosylceramidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables galactosylceramidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables hydrolase activity, acting on glycosyl bonds IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in galactosylceramide catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within galactosylceramide catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within lipid catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within sphingolipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in lysosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in lysosome IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    galactocerebrosidase
    NP_998276.2
    XP_068070479.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_213111.2NP_998276.2  galactocerebrosidase precursor

      Status: VALIDATED

      Source sequence(s)
      CU571402
      UniProtKB/TrEMBL
      Q7ZUD5
      Related
      ENSDARP00000018263.7, ENSDART00000028044.8

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007128.7 Reference GRCz11 Primary Assembly

      Range
      18889126..18898082 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068214378.1XP_068070479.1  galactocerebrosidase isoform X1

      UniProtKB/TrEMBL
      Q7ZUD5