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    Nepl11 Neprilysin-like 11 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40540, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Nepl11provided by FlyBase
    Official Full Name
    Neprilysin-like 11provided by FlyBase
    Primary source
    FLYBASE:FBgn0037230
    Locus tag
    Dmel_CG9780
    See related
    AllianceGenome:FB:FBgn0037230
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG9780; Dmel\CG9780
    Summary
    Predicted to be involved in proteolysis. Predicted to be active in plasma membrane. Is expressed in adult head and embryonic/larval fat body. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Nepl11 in Genome Data Viewer
    Location:
    82A1-82A1; 3-47.1 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (4292274..4294840, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (117996..120562, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene flippy Neighboring gene long non-coding RNA:CR45597 Neighboring gene complexin Neighboring gene mir-929 stem loop Neighboring gene Vacuolar protein sorting 24 Neighboring gene Melanization Protease 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Binding of SU(VAR)3-9 Partially Depends on SETDB1 in the Chromosomes of Drosophila melanogaster. Maksimov DA, et al. Cells, 2019 Sep 5. PMID 31491894, Free PMC Article
    2. Neprilysins: an evolutionarily conserved family of metalloproteases that play important roles in reproduction in Drosophila. Sitnik JL, et al. Genetics, 2014 Mar. PMID 24395329, Free PMC Article
    3. Identification and bioinformatic analysis of neprilysin and neprilysin-like metalloendopeptidases in Drosophila melanogaster. Meyer H, et al. MicroPubl Biol, 2021 Jun 23. PMID 34189422, Free PMC Article
    4. Juvenile hormone counteracts the bHLH-PAS transcription factors MET and GCE to prevent caspase-dependent programmed cell death in Drosophila. Liu Y, et al. Development, 2009 Jun. PMID 19465595
    5. Identification of circadian-clock-regulated enhancers and genes of Drosophila melanogaster by transposon mobilization and luciferase reporting of cyclical gene expression. Stempfl T, et al. Genetics, 2002 Feb. PMID 11861563, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    • Annotated by Drosophila Heterochromatin Genome Project, Lawrence Berkeley National Lab, http://www.dhgp.org

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    NOT enables peptidase activity IKR
    Inferred from Key Residues
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Neprilysin-like 11
    Names
    CG9780-PA
    Nepl11-PA
    neprilysin

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      4292274..4294840 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_141192.3 → NP_649449.1  Neprilysin-like 11 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649449.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VN01
      Related
      FBpp0078599
      Conserved Domains (1) summary
      cl14813
      Location:45 → 589
      GluZincin; Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VN01 Q9VN01

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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