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    nAChRalpha4 nicotinic Acetylcholine Receptor alpha4 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40521, updated on 9-Dec-2024

    Summary

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    Official Symbol
    nAChRalpha4provided by FlyBase
    Official Full Name
    nicotinic Acetylcholine Receptor alpha4provided by FlyBase
    Primary source
    FLYBASE:FBgn0266347
    Locus tag
    Dmel_CG12414
    See related
    AllianceGenome:FB:FBgn0266347
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    alpha4; anon-WO0138359.1; CG12414; CG17552; Dalpha4; Dmel\CG12414; nAChR; nAChR-alpha80B; nAChRa4; nAcRalpha-4; nAcRalpha-80; nAcRalpha-80B; nAcRaplha-80B; redeye; rye
    Summary
    Contributes to acetylcholine receptor activity. Involved in sleep. Part of acetylcholine-gated channel complex. Is expressed in adult head; lamina monopolar neuron L4; and organism. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; autosomal dominant nocturnal frontal lobe epilepsy (multiple); congenital myasthenic syndrome (multiple); gastrointestinal system cancer (multiple); and respiratory system cancer (multiple). Orthologous to several human genes including CHRNA6 (cholinergic receptor nicotinic alpha 6 subunit). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See nAChRalpha4 in Genome Data Viewer
    Location:
    80D5-80E3; 3-47 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (23206669..23287448)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (23199769..23280548)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR43967 Neighboring gene long non-coding RNA:CR45735 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR46475 Neighboring gene alpha Catenin Neighboring gene mir-4942 stem loop Neighboring gene NADH dehydrogenase (ubiquinone) MLRQ subunit

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Propose that the homeostatic drive to sleep increases levels of RYE, which responds to this drive by promoting sleep.
      Title: Identification of Redeye, a new sleep-regulating protein whose expression is modulated by sleep amount.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    mobile_element

    • Loc: 23214034-23214082 mobile_element_type = transposon:INE-1{}3754
    • Loc: 23218788-23219072 mobile_element_type = transposon:INE-1{}3758
    • Loc: 23219681-23219797 mobile_element_type = transposon:297{}3807
    • Loc: 23219852-23224264 mobile_element_type = transposon:X{}1606
    • Loc: 23228423-23228527 mobile_element_type = transposon:INE-1{}3769
    • Loc: 23241916-23243038 mobile_element_type = transposon:1360{}1171
    • Loc: 23248105-23248334 mobile_element_type = transposon:INE-1{}4510
    • Loc: 23252656-23252973 mobile_element_type = transposon:INE-1{}4512
    • Loc: 23256350-23256483 mobile_element_type = transposon:G5{}5176
    • Loc: 23267007-23267531 mobile_element_type = transposon:Cr1a{}1170
    • Loc: 23271761-23276816 mobile_element_type = transposon:invader2{}1169
    • Loc: 23277858-23277953 mobile_element_type = transposon:INE-1{}4524
    • Loc: 23279422-23279467 mobile_element_type = transposon:Cr1a{}5145
    • Loc: 23279468-23283577 mobile_element_type = transposon:Cr1a{}1607
    • Loc: 23279613-23279961 mobile_element_type = transposon:gypsy8{}5279
    • Loc: 23282059-23283258 mobile_element_type = transposon:looper1{}5747
    • Loc: 23286500-23286608 mobile_element_type = transposon:INE-1{}4535

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    contributes_to acetylcholine receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables acetylcholine-gated monoatomic cation-selective channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables acetylcholine-gated monoatomic cation-selective channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables extracellular ligand-gated monoatomic ion channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmembrane signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chemical synaptic transmission IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in monoatomic ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in monoatomic ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of membrane potential IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sleep IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of acetylcholine-gated channel complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of acetylcholine-gated channel complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in postsynaptic membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    nicotinic acetylcholine receptor alpha4
    Names
    CG12414-PC
    CG12414-PD
    CG12414-PE
    CG12414-PF
    CG12414-PG
    CG12414-PH
    Dalpha4
    nAChRalpha4-PC
    nAChRalpha4-PD
    nAChRalpha4-PE
    nAChRalpha4-PF
    nAChRalpha4-PG
    nAChRalpha4-PH
    nicotinic acetylcholine receptor alpha 4
    nicotinic acetylcholine receptor alpha 80B
    red-eye
    redeye
    NP_001097669.2
    • unusual splice
    NP_001246895.1
    • unusual splice
    NP_001246896.1
    • unusual splice
    NP_001303394.1
    • unusual splice
    NP_536742.3
    • unusual splice

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      23206669..23287448
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001104199.5 → NP_001097669.2  nicotinic acetylcholine receptor alpha4, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097669.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8JNX5, Q9NFR5
      Conserved Domains (3) summary
      TIGR00860
      Location:1 → 505
      LIC; Cation transporter family protein
      pfam02931
      Location:12 → 227
      Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
      pfam02932
      Location:234 → 505
      Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region

    2. NM_001316465.1 → NP_001303394.1  nicotinic acetylcholine receptor alpha4, isoform H [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0S0WNY8, Q9NFR5
      Conserved Domains (3) summary
      TIGR00860
      Location:1 → 505
      LIC; Cation transporter family protein
      pfam02931
      Location:12 → 227
      Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
      pfam02932
      Location:234 → 505
      Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region

    3. NM_001259966.3 → NP_001246895.1  nicotinic acetylcholine receptor alpha4, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246895.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9NE13, Q058T0
      Conserved Domains (2) summary
      pfam02931
      Location:3 → 59
      Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
      pfam02932
      Location:66 → 337
      Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region

    4. NM_001259967.2 → NP_001246896.1  nicotinic acetylcholine receptor alpha4, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246896.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9NE13, Q058T0
      Conserved Domains (2) summary
      pfam02931
      Location:3 → 59
      Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
      pfam02932
      Location:66 → 337
      Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region

    5. NM_001275305.1 → NP_001262234.1  nicotinic acetylcholine receptor alpha4, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262234.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PDC9, Q9NFR5
      Conserved Domains (3) summary
      TIGR00860
      Location:1 → 465
      LIC; Cation transporter family protein
      pfam02931
      Location:12 → 227
      Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
      pfam02932
      Location:234 → 465
      Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region

    6. NM_080494.3 → NP_536742.3  nicotinic acetylcholine receptor alpha4, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_536742.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q058T0, Q95RL8
      Conserved Domains (2) summary
      pfam02931
      Location:6 → 72
      Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
      pfam02932
      Location:79 → 350
      Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0S0WNY8 A0A0S0WNY8
    A8JNX5 A8JNX5
    M9NE13 M9NE13
    M9PDC9 M9PDC9
    Q95RL8 Q95RL8
    Q9NFR4 Q9NFR4
    Q9NFR5 Q9NFR5

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