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    POLY polyprotein [ Hepacivirus P ]

    Gene ID: 40338758, updated on 1-Aug-2022

    Summary

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    Gene symbol
    POLY
    Gene description
    polyprotein
    Locus tag
    EXL41_gp1
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Hepacivirus P (isolate: RHV-GS2015, nat-host: ground squirrel (Citellus dauricus Brandt))
    Lineage
    Viruses; Riboviria; Flaviviridae; Hepacivirus; unclassified Hepacivirus
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    Genomic context

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    Sequence:
    NC_040815.1 (175..8469)

    NC_040815.1Genomic Context describing neighboring genes

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_040815.1

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    GeneRIFs: Gene References Into Functions

    General protein information

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    Preferred Names
    polyprotein
    Names
    core protein C
    envelope protein E1
    envelope protein E2
    protein p7
    nonstructural protein NS2
    protease-helicase NS3
    nonstructural protein NS4A
    nonstructural protein NS4B
    nonstructural protein NS5A
    RNA-dependent RNA polymerase NS5B

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_040815.1 Reference assembly

      Range
      175..8469
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. YP_009553586.1 polyprotein [Hepacivirus P]

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A2U8N593
      Conserved Domains (9) summary
      pfam01001
      Location:1550 → 1739
      HCV_NS4b; Hepatitis C virus non-structural protein NS4b
      pfam01539
      Location:158 → 332
      HCV_env; Hepatitis C virus envelope glycoprotein E1
      pfam02907
      Location:895 → 1037
      Peptidase_S29; Hepatitis C virus NS3 protease
      pfam08301
      Location:1889 → 1950
      HCV_NS5a_1b; Hepatitis C virus non-structural 5a domain 1b
      pfam01542
      Location:82 → 149
      HCV_core; Hepatitis C virus core protein
      pfam08300
      Location:1826 → 1884
      HCV_NS5a_1a; Hepatitis C virus non-structural 5a zinc finger domain
      pfam00998
      Location:2187 → 2687
      RdRP_3; Viral RNA dependent RNA polymerase
      cl28899
      Location:1061 → 1202
      DEAD-like_helicase_N; N-terminal helicase domain of the DEAD-box helicase superfamily
      cl38915
      Location:1199 → 1331
      DEAD-like_helicase_C; C-terminal helicase domain of the DEAD-like helicases

    2. YP_009709871.1 core protein C

      Conserved Domains (1) summary
      pfam01542
      Location:82 → 149
      HCV_core; Hepatitis C virus core protein

    3. YP_009709872.1 envelope protein E1

      Conserved Domains (1) summary
      pfam01539
      Location:5 → 179
      HCV_env; Hepatitis C virus envelope glycoprotein E1

    4. YP_009709873.1 envelope protein E2

    5. YP_009709874.1 protein p7

    6. YP_009709875.1 nonstructural protein NS2

    7. YP_009709876.1 protease-helicase NS3

      Conserved Domains (3) summary
      cl38915
      Location:335 → 467
      DEAD-like_helicase_C; C-terminal helicase domain of the DEAD-like helicases
      pfam02907
      Location:31 → 173
      Peptidase_S29; Hepatitis C virus NS3 protease
      cl28899
      Location:197 → 338
      DEAD-like_helicase_N; N-terminal helicase domain of the DEAD-box helicase superfamily

    8. YP_009709877.1 nonstructural protein NS4A

    9. YP_009709878.1 nonstructural protein NS4B

      Conserved Domains (1) summary
      pfam01001
      Location:6 → 195
      HCV_NS4b; Hepatitis C virus non-structural protein NS4b

    10. YP_009709879.1 nonstructural protein NS5A

      Conserved Domains (2) summary
      pfam08301
      Location:100 → 161
      HCV_NS5a_1b; Hepatitis C virus non-structural 5a domain 1b
      pfam08300
      Location:37 → 85
      HCV_NS5a_1a; Hepatitis C virus non-structural 5a zinc finger domain

    11. YP_009709880.1 RNA-dependent RNA polymerase NS5B

      Conserved Domains (1) summary
      cl02808
      Location:3 → 503
      RT_like; Reverse transcriptase (RT, RNA-dependent DNA polymerase)_like family. An RT gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. RTs occur in a variety of mobile elements, including retrotransposons, retroviruses, group ...
    Nucleotide Protein
    Heading Accession and Version

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