gli3 GLI family zinc finger 3 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: gli3provided by ZNC
Official Full Name: GLI family zinc finger 3provided by ZNC
Primary source: ZFIN:ZDB-GENE-041111-162
See related: Ensembl:ENSDARG00000052131 AllianceGenome:ZFIN:ZDB-GENE-041111-162
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: fpr; im:7142603
Summary: Enables DNA-binding transcription factor activity, RNA polymerase II-specific. Involved in negative regulation of transcription by RNA polymerase II. Acts upstream of or within generation of neurons and regulation of neurogenesis. Is active in chromatin. Is expressed in several structures, including brain; ceratohyal cartilage; hindbrain neural tube; neural keel; and neural rod. Human ortholog(s) of this gene implicated in Greig cephalopolysyndactyly syndrome; Pallister-Hall syndrome; anodontia; polydactyly; and syndactyly. Orthologous to human GLI3 (GLI family zinc finger 3). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: chromosome: 24

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	24	NC_007135.7 (11529877..11821505, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	24	NC_007135.6 (11389510..11681138, complement)

Chromosome 24 - NC_007135.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Zebrafish Gli3 functions as both an activator and a repressor in Hedgehog signaling. In the eye, Gli3 is also required for proper ath5 expression and the differentiation of retinal ganglion cells.
Title: Zebrafish Gli3 functions as both an activator and a repressor in Hedgehog signaling.

Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within generation of neurons	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within generation of neurons	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info	PubMed
acts_upstream_of_or_within regulation of neurogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in smoothened signaling pathway	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in chromatin	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

Go to the top of the page Help

Preferred Names: transcriptional activator GLI3

Names: GLI-Kruppel family member GLI3; zinc finger transcription factor Gli3

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_205728.1 → NP_991291.1 transcriptional activator GLI3

See identical proteins and their annotated locations for NP_991291.1

Status: PROVISIONAL

Source sequence(s)

AY377429

UniProtKB/TrEMBL

Q6U6Z9

Related

ENSDARP00000058991.7, ENSDART00000058992.8

Conserved Domains (2) summary

sd00017
Location:524 → 546

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam13465
Location:538 → 565

zf-H2C2_2; Zinc-finger double domain