Six4 Six4 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Six4provided by FlyBase
Official Full Name: Six4provided by FlyBase
Primary source: FLYBASE:FBgn0027364
Locus tag: Dmel_CG3871
See related: AllianceGenome:FB:FBgn0027364
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG3871; D-six4; D-Six4; Dmel\CG3871; Dsix4; DSix4; six4; six4/5
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including fat body development; gonad development; and myoblast fusion. Predicted to be part of transcription regulator complex. Predicted to be active in nucleus. Is expressed in several structures, including anlage in statu nascendi; antennal anlage; ganglia; mesoderm; and somatic cell of ovariole. Human ortholog(s) of this gene implicated in branchiootorenal syndrome 2. Orthologous to human SIX4 (SIX homeobox 4) and SIX5 (SIX homeobox 5). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (20788886..20792777, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (20781986..20785877, complement)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Homeodomain protein Six4 prevents the generation of supernumerary Drosophila type II neuroblasts and premature differentiation of intermediate neural progenitors.
Title: Homeodomain protein Six4 prevents the generation of supernumerary Drosophila type II neuroblasts and premature differentiation of intermediate neural progenitors.
Six4 and Gro promote differentiation towards the polar cell fate by promoting Notch pathway activity.
Title: Phosphorylated Groucho delays differentiation in the follicle stem cell lineage by providing a molecular memory of EGFR signaling in the niche.
D-six4 is a key mesodermal patterning mediator that regulates a variety of cell-type-specific factors and hence plays an equivalent role to tin.
Title: D-six4 plays a key role in patterning cell identities deriving from the Drosophila mesoderm.
Six4 is a key regulator of somatic cell function during gonadogenesis
Title: Live imaging of Drosophila gonad formation reveals roles for Six4 in regulating germline and somatic cell migration.

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in fat body development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in gonad development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mesoderm development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in myoblast fusion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
part_of transcription regulator complex	IBA Inferred from Biological aspect of Ancestor more info

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