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    Cyp305a1 Cytochrome P450 305a1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40161, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cyp305a1provided by FlyBase
    Official Full Name
    Cytochrome P450 305a1provided by FlyBase
    Primary source
    FLYBASE:FBgn0036910
    Locus tag
    Dmel_CG8733
    See related
    AllianceGenome:FB:FBgn0036910
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    305a1; AAF49108.1; CG8733; Cyp305A1; CYP305A1; CYP305A1-Dm; Dmel\CG8733
    Summary
    Predicted to enable several functions, including heme binding activity; iron ion binding activity; and monooxygenase activity. Is expressed in several structures, including adult head; anterior endoderm; embryonic epipharynx; embryonic hindgut; and embryonic optic lobe primordium. Human ortholog(s) of this gene implicated in several diseases, including drug dependence (multiple); hypertension (multiple); neonatal abstinence syndrome; nicotine dependence; and renal fibrosis. Orthologous to human CYP2B6 (cytochrome P450 family 2 subfamily B member 6); CYP2J2 (cytochrome P450 family 2 subfamily J member 2); and CYP2W1 (cytochrome P450 family 2 subfamily W member 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Cyp305a1 in Genome Data Viewer
    Location:
    76C6-76C6; 3-46 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (19810403..19813339, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (19803503..19806439, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Coiled-coil domain-containing 58 Neighboring gene karyopherin alpha1 Neighboring gene uncharacterized protein Neighboring gene cycle Neighboring gene fibp

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cyp6g2 is the major P450 epoxidase responsible for juvenile hormone biosynthesis in Drosophila melanogaster. Jia Q, et al. BMC Biol, 2024 May 13. PMID 38741075, Free PMC Article
    2. Association of detoxification enzymes with butene-fipronil in larvae and adults of Drosophila melanogaster. Arain MS, et al. Environ Sci Pollut Res Int, 2018 Apr. PMID 29380196
    3. The involvement of cytochrome P450 monooxygenases in methanol elimination in Drosophila melanogaster larvae. Wang SP, et al. Arch Insect Biochem Physiol, 2012 Apr. PMID 22508581
    4. Transcript level is a key factor affecting RNAi efficiency. Chen J, et al. Pestic Biochem Physiol, 2021 Jul. PMID 34119217
    5. The involvement of several enzymes in methanol detoxification in Drosophila melanogaster adults. Wang SP, et al. Comp Biochem Physiol B Biochem Mol Biol, 2013 Sep. PMID 23751173

    See all (49) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables monooxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    cytochrome P450 305a1
    Names
    CG8733-PA
    Cyp305a1-PA
    cytochrome P450
    NP_649151.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      19810403..19813339 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_140894.3 → NP_649151.1  cytochrome P450 305a1 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649151.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VW43
      Related
      FBpp0074694
      Conserved Domains (1) summary
      pfam00067
      Location:30 → 500
      p450; Cytochrome P450
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VW43.1 Q9VW43

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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