U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    Ir76a Ionotropic receptor 76a [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40157, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Ir76aprovided by FlyBase
    Official Full Name
    Ionotropic receptor 76aprovided by FlyBase
    Primary source
    FLYBASE:FBgn0260874
    Locus tag
    Dmel_CG42584
    See related
    AllianceGenome:FB:FBgn0260874
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    76a; CG34257; CG42584; CG8533; CT24909; DmelIR76a; Dmel\CG42584; ir76a; IR76a
    Old locus tag
    Dmel_CG34257; Dmel_CG8533
    Summary
    Contributes to olfactory receptor activity. Involved in detection of chemical stimulus involved in sensory perception of smell and transmission of nerve impulse. Located in sensory dendrite. Part of receptor complex. Is expressed in adult olfactory receptor neuron Ir76a; antennal coeloconic sensillum ac4; and antennal lobe glomerulus VM4. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Ir76a in Genome Data Viewer
    Location:
    76C6-76C6; 3-46 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (19799278..19803427)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (19792378..19796527)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Guanylyl cyclase at 76C Neighboring gene Viral tegument-like deubiquitinase Neighboring gene Sterol regulatory element binding protein Neighboring gene uncharacterized protein Neighboring gene mir-33 stem loop Neighboring gene uncharacterized protein Neighboring gene Torsin interacting protein Neighboring gene Coiled-coil domain-containing 58

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Dedicated olfactory neurons mediating attraction behavior to ammonia and amines in Drosophila. Min S, et al. Proc Natl Acad Sci U S A, 2013 Apr 2. PMID 23509267, Free PMC Article
    2. Ion Channel Contributions to Wing Development in Drosophila melanogaster. George LF, et al. G3 (Bethesda), 2019 Apr 9. PMID 30733380, Free PMC Article
    3. Functional architecture of olfactory ionotropic glutamate receptors. Abuin L, et al. Neuron, 2011 Jan 13. PMID 21220098, Free PMC Article
    4. Two new and distinct roles for Drosophila Argonaute-2 in the nucleus: alternative pre-mRNA splicing and transcriptional repression. Taliaferro JM, et al. Genes Dev, 2013 Feb 15. PMID 23392611, Free PMC Article
    5. An ammonium transporter is a non-canonical olfactory receptor for ammonia. Vulpe A, et al. Curr Biol, 2021 Aug 9. PMID 34111404, Free PMC Article

    See all (57) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ligand-gated monoatomic ion channel activity ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    contributes_to olfactory receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in detection of chemical stimulus involved in sensory perception IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in detection of chemical stimulus involved in sensory perception of smell IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in transmission of nerve impulse IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    part_of receptor complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in sensory dendrite IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    ionotropic receptor 76a
    Names
    CG42584-PA
    CG42584-PB
    CG42584-PD
    CG42584-PE
    Ir76a-PA
    Ir76a-PB
    Ir76a-PD
    Ir76a-PE

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      19799278..19803427
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001104177.3 → NP_001097647.3  ionotropic receptor 76a, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097647.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8JNV9, C0JXA4

    2. NM_168817.3 → NP_730452.2  ionotropic receptor 76a, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_730452.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      C6TPB7, Q9VW39
      Related
      FBpp0290818
      Conserved Domains (1) summary
      smart00079
      Location:156 → 228
      PBPe; Eukaryotic homologues of bacterial periplasmic substrate binding proteins. Prokaryotic homologues are represented by a separate alignment: PBPb

    3. NM_001144510.3 → NP_001137982.1  ionotropic receptor 76a, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001137982.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B7Z084

    4. NM_140891.4 → NP_649148.2  ionotropic receptor 76a, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649148.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      C6TPB7, Q9VW39
      Related
      FBpp0290819
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A8JNV9 A8JNV9
    B7Z084 B7Z084
    Q7KUT6 Q7KUT6
    Q9VW39 Q9VW39

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools