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    CG42637 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40153, updated on 4-Jan-2025

    Summary

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    Official Symbol
    CG42637provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0261360
    Locus tag
    Dmel_CG42637
    See related
    AllianceGenome:FB:FBgn0261360
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG42637
    Old locus tag
    Dmel_CG8742
    Summary
    Predicted to enable guanylate cyclase activity and signaling receptor activity. Predicted to be involved in cGMP-mediated signaling. Predicted to be located in plasma membrane. Is expressed in adult head. [provided by Alliance of Genome Resources, Jan 2025]
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    Genomic context

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    See CG42637 in Genome Data Viewer
    Location:
    76C2-76C5; 3-46 cM
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (19719527..19793569, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (19712627..19786669, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene serpentine Neighboring gene Transient receptor potential cation channel, mucolipin Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Guanylyl cyclase at 76C Neighboring gene Viral tegument-like deubiquitinase Neighboring gene Sterol regulatory element binding protein Neighboring gene uncharacterized protein Neighboring gene mir-33 stem loop Neighboring gene Ionotropic receptor 76a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Drosophila receptor guanylyl cyclase Gyc76C is required for semaphorin-1a-plexin A-mediated axonal repulsion. Ayoob JC, et al. J Neurosci, 2004 Jul 28. PMID 15282266, Free PMC Article
    2. Molecular genetic analysis of Chd3 and polytene chromosome region 76B-D in Drosophila melanogaster. Cooper MT, et al. Genetics, 2010 Jul. PMID 20439780, Free PMC Article
    3. Phylogenetic investigation of Peptide hormone and growth factor receptors in five dipteran genomes. Vogel KJ, et al. Front Endocrinol (Lausanne), 2013. PMID 24379806, Free PMC Article
    4. Combining genetic perturbations and proteomics to examine kinase-phosphatase networks in Drosophila embryos. Sopko R, et al. Dev Cell, 2014 Oct 13. PMID 25284370, Free PMC Article
    5. In vivo analysis of proteomes and interactomes using Parallel Affinity Capture (iPAC) coupled to mass spectrometry. Rees JS, et al. Mol Cell Proteomics, 2011 Jun. PMID 21447707, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    mobile_element

    • Loc: c19776073-19771346 mobile_element_type = transposon:Doc{}1053

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables guanylate cyclase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables phosphorus-oxygen lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    NOT enables protein kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables signaling receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in cGMP-mediated signaling ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in cyclic nucleotide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG42637-PA
    CG42637-PB
    CG42637-PC
    NP_001007096.1
    NP_001007097.1
    NP_524165.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      19719527..19793569 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001007096.3 → NP_001007097.1  uncharacterized protein Dmel_CG42637, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001007097.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q24051, Q7JQ32
      UniProtKB/TrEMBL
      A4V243
      Conserved Domains (6) summary
      cd06370
      Location:26 → 445
      PBP1_Speract_GC_like; Ligand-binding domain of membrane bound guanylyl cyclases
      smart00044
      Location:860 → 1052
      CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
      cd14042
      Location:543 → 827
      PK_GC-A_B; Pseudokinase domain of the membrane Guanylate Cyclase receptors, GC-A and GC-B
      pfam00211
      Location:887 → 1074
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam01094
      Location:48 → 412
      ANF_receptor; Receptor family ligand binding region
      pfam07701
      Location:835 → 881
      HNOBA; Heme NO binding associated

    2. NM_001007095.3 → NP_001007096.1  uncharacterized protein Dmel_CG42637, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001007096.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q24051, Q7JQ32
      UniProtKB/TrEMBL
      A4V243
      Conserved Domains (6) summary
      cd06370
      Location:26 → 445
      PBP1_Speract_GC_like; Ligand-binding domain of membrane bound guanylyl cyclases
      smart00044
      Location:860 → 1052
      CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
      cd14042
      Location:543 → 827
      PK_GC-A_B; Pseudokinase domain of the membrane Guanylate Cyclase receptors, GC-A and GC-B
      pfam00211
      Location:887 → 1074
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam01094
      Location:48 → 412
      ANF_receptor; Receptor family ligand binding region
      pfam07701
      Location:835 → 881
      HNOBA; Heme NO binding associated

    3. NM_079441.4 → NP_524165.2  uncharacterized protein Dmel_CG42637, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524165.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q24051, Q7JQ32
      UniProtKB/TrEMBL
      A4V243
      Conserved Domains (6) summary
      cd06370
      Location:26 → 445
      PBP1_Speract_GC_like; Ligand-binding domain of membrane bound guanylyl cyclases
      smart00044
      Location:860 → 1052
      CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
      cd14042
      Location:543 → 827
      PK_GC-A_B; Pseudokinase domain of the membrane Guanylate Cyclase receptors, GC-A and GC-B
      pfam00211
      Location:887 → 1074
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam01094
      Location:48 → 412
      ANF_receptor; Receptor family ligand binding region
      pfam07701
      Location:835 → 881
      HNOBA; Heme NO binding associated
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A4V243 A4V243
    Q7JQ32.1

    Gene LinkOut

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