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    RAB19 RAB19, member RAS oncogene family [ Homo sapiens (human) ]

    Gene ID: 401409, updated on 10-Dec-2024

    Summary

    Official Symbol
    RAB19provided by HGNC
    Official Full Name
    RAB19, member RAS oncogene familyprovided by HGNC
    Primary source
    HGNC:HGNC:19982
    See related
    Ensembl:ENSG00000146955 AllianceGenome:HGNC:19982
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RAB19B
    Summary
    Predicted to enable GTPase activity. Predicted to be involved in autophagosome assembly and intracellular protein transport. Located in extracellular exosome. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in colon (RPKM 1.1), thyroid (RPKM 1.0) and 15 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See RAB19 in Genome Data Viewer
    Location:
    7q34
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (140404058..140427974)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (141718006..141742144)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (140103858..140127774)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene solute carrier family 37 member 3 Neighboring gene small nucleolar RNA U13 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26779 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:140089807-140090308 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:140090309-140090808 Neighboring gene RNA, 5S ribosomal pseudogene 248 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18710 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18711 Neighboring gene uncharacterized LOC124901759 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:140103431-140103932 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:140103933-140104432 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26781 Neighboring gene nucleoside diphosphate kinase, mitochondrial-like Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:140143760-140144260 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:140156257-140157110 Neighboring gene makorin ring finger protein 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:140178571-140179411

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in autophagosome assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in endomembrane system IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular exosome HDA PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    ras-related protein Rab-19
    Names
    GTP-binding protein RAB19B

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001008749.3NP_001008749.2  ras-related protein Rab-19

      See identical proteins and their annotated locations for NP_001008749.2

      Status: VALIDATED

      Source sequence(s)
      AC069335, BC140796, DN996121, DY655778
      Consensus CDS
      CCDS34762.2
      UniProtKB/Swiss-Prot
      A4D1S5, A4D1S6, B2RTS6, B5MDR2, Q9UL27
      Related
      ENSP00000440167.1, ENST00000537763.6
      Conserved Domains (1) summary
      cd01864
      Location:15179
      Rab19; Rab GTPase family 19 (Rab19)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      140404058..140427974
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005249997.4XP_005250054.1  ras-related protein Rab-19 isoform X2

      Conserved Domains (2) summary
      cd01864
      Location:15167
      Rab19; Rab GTPase family 19 (Rab19)
      smart00175
      Location:18170
      RAB; Rab subfamily of small GTPases
    2. XM_005249998.4XP_005250055.1  ras-related protein Rab-19 isoform X3

      Conserved Domains (2) summary
      smart00175
      Location:18168
      RAB; Rab subfamily of small GTPases
      cl21455
      Location:15165
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    3. XM_005249996.4XP_005250053.1  ras-related protein Rab-19 isoform X1

      See identical proteins and their annotated locations for XP_005250053.1

      UniProtKB/Swiss-Prot
      A4D1S5, A4D1S6, B2RTS6, B5MDR2, Q9UL27
      Related
      ENSP00000348778.3, ENST00000356407.3
      Conserved Domains (1) summary
      cd01864
      Location:15179
      Rab19; Rab GTPase family 19 (Rab19)
    4. XM_047420375.1XP_047276331.1  ras-related protein Rab-19 isoform X2

    5. XM_017012207.2XP_016867696.1  ras-related protein Rab-19 isoform X1

      UniProtKB/Swiss-Prot
      A4D1S5, A4D1S6, B2RTS6, B5MDR2, Q9UL27
      Conserved Domains (1) summary
      cd01864
      Location:15179
      Rab19; Rab GTPase family 19 (Rab19)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      141718006..141742144
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054358219.1XP_054214194.1  ras-related protein Rab-19 isoform X2

    2. XM_054358216.1XP_054214191.1  ras-related protein Rab-19 isoform X1

      UniProtKB/Swiss-Prot
      A4D1S5, A4D1S6, B2RTS6, B5MDR2, Q9UL27
    3. XM_054358218.1XP_054214193.1  ras-related protein Rab-19 isoform X2

    4. XM_054358220.1XP_054214195.1  ras-related protein Rab-19 isoform X3

    5. XM_054358217.1XP_054214192.1  ras-related protein Rab-19 isoform X1

      UniProtKB/Swiss-Prot
      A4D1S5, A4D1S6, B2RTS6, B5MDR2, Q9UL27