U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    COX6AL2 Cytochrome c oxidase subunit 6A-like 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40066, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    COX6AL2provided by FlyBase
    Official Full Name
    Cytochrome c oxidase subunit 6A-like 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0036830
    Locus tag
    Dmel_CG14077
    See related
    AllianceGenome:FB:FBgn0036830
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG14077; Dmel\CG14077; VIa
    Summary
    Predicted to enable enzyme regulator activity. Predicted to be involved in mitochondrial electron transport, cytochrome c to oxygen. Predicted to be located in mitochondrial inner membrane. Predicted to be part of respiratory chain complex IV. Is expressed in adult head and spermatozoon. Human ortholog(s) of this gene implicated in mitochondrial complex IV deficiency nuclear type 18. Orthologous to human COX6A2 (cytochrome c oxidase subunit 6A2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See COX6AL2 in Genome Data Viewer
    Location:
    75E5-75E5; 3-45 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (18908260..18914150, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (18901360..18907250, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene COP9 signalosome subunit 1b Neighboring gene pre-mRNA processing factor 6 Neighboring gene Ionotropic receptor 75d Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Compartment specific mitochondrial dysfunction in Drosophila knock-in model of ALS reversed by altered gene expression of OXPHOS subunits and pro-fission factor Drp1. Nemtsova Y, et al. Mol Cell Neurosci, 2023 Jun. PMID 36868541, Free PMC Article
    2. The cyclope gene of Drosophila encodes a cytochrome c oxidase subunit VIc homolog. Szuplewski S, et al. Genetics, 2001 Aug. PMID 11514451, Free PMC Article
    3. Drosophila Charcot-Marie-Tooth Disease Models. Yamaguchi M, et al. Adv Exp Med Biol, 2018. PMID 29951817
    4. Recent Advances in Drosophila Models of Charcot-Marie-Tooth Disease. Kitani-Morii F, et al. Int J Mol Sci, 2020 Oct 8. PMID 33049996, Free PMC Article
    5. Molecular pathogenesis of peripheral neuropathies: insights from Drosophila models. Bussmann J, et al. Curr Opin Genet Dev, 2017 Jun. PMID 28213160

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables enzyme regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitochondrial electron transport, cytochrome c to oxygen IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of respiratory chain complex IV IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    cytochrome c oxidase subunit 6A-like 2
    Names
    CG14077-PB
    CG14077-PC
    COX6AL2-PB
    COX6AL2-PC

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      18908260..18914150 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_140818.3 → NP_649075.1  cytochrome c oxidase subunit 6A-like 2, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649075.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VVU8
      Related
      FBpp0289099
      Conserved Domains (1) summary
      cd00925
      Location:146 → 229
      Cyt_c_Oxidase_VIa; Cytochrome c oxidase subunit VIa. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of ...

    2. NM_001259899.1 → NP_001246828.1  cytochrome c oxidase subunit 6A-like 2, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246828.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VVU8
      Conserved Domains (1) summary
      cd00925
      Location:146 → 229
      Cyt_c_Oxidase_VIa; Cytochrome c oxidase subunit VIa. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VVU8 Q9VVU8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.