gsk3b.L glycogen synthase kinase 3 beta L homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: gsk3b.L
Official Full Name: glycogen synthase kinase 3 beta L homeolog
Primary source: Xenbase:XB-GENE-865674
Locus tag: XELAEV_180112401mg
See related: EnsemblRapid:ENSXLAG00005024745 AllianceGenome:Xenbase:XB-GENE-865674
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: gsk3; gsk-3; gsk3b; xgsk-3; gsk3beta; gsk3-beta
Summary: Predicted to enable protein serine/threonine kinase activity. Acts upstream of or within negative regulation of DNA-templated transcription and negative regulation of canonical Wnt signaling pathway. Predicted to be located in cytoplasm; nucleus; and plasma membrane. Is expressed in ectoderm and vestibuloauditory system. Human ortholog(s) of this gene implicated in Alzheimer's disease; amyotrophic lateral sclerosis; bipolar disorder; oral squamous cell carcinoma; and schizophrenia. Orthologous to human GSK3B (glycogen synthase kinase 3 beta). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

Location:: chromosome: 2L

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	2L	NC_054373.1 (1342920..1392653)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	2L	NC_030726.1 (1341267..1392559)

Chromosome 2L - NC_054373.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Results find that knockdown of Jmjd6a led to deletion of GSK3beta RNA exon 1 and 2, which resulted in generation of N'-terminal truncated GSK3beta protein suggesting that GSK3beta RNA splicing is regulated by Jmjd6a during Xenopus laevis eye development.
Title: Jmjd6a regulates GSK3β RNA splicing in Xenopus laevis eye development.
Novel roles for Plk and GSK3 regulation of ADAM13 function in cranial neural crest cell migration.
Title: GSK3 and Polo-like kinase regulate ADAM13 function during cranial neural crest cell migration.
Interaction with Snail1/2, and Twist function more generally, is regulated by GSK-3-beta-mediated phosphorylation of conserved sites in the WR domain.
Title: Interactions between Twist and other core epithelial-mesenchymal transition factors are controlled by GSK3-mediated phosphorylation.
These data suggest that the interactions of beta-catenin with alpha-catenin and GSK-3beta exert opposing effects on the terminal projections of ventral optic axons.
Title: GSK-3beta and alpha-catenin binding regions of beta-catenin exert opposing effects on the terminal ventral optic axonal projection.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables tau-protein kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of canonical Wnt signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of epithelial to mesenchymal transition	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within negative regulation of signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within nervous system development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within rhythmic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: glycogen synthase kinase-3 beta

Names: GSK-3 beta; intracellular kinase

NP_001083752.1

EC 2.7.11.26

XP_018100413.1

EC 2.7.11.26

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001090283.1 → NP_001083752.1 glycogen synthase kinase-3 beta

See identical proteins and their annotated locations for NP_001083752.1

Status: PROVISIONAL

Source sequence(s)

BC108581

UniProtKB/Swiss-Prot

Q91627, Q91757

Related

ENSXLAP00005073621.1, ENSXLAT00005075186.1

Conserved Domains (2) summary

cd14137
Location:51 → 343

STKc_GSK3; The catalytic domain of the Serine/Threonine Kinase, Glycogen Synthase Kinase 3

pfam00069
Location:56 → 340

Pkinase; Protein kinase domain