cxcl12.L C-X-C motif chemokine ligand 12 L homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: cxcl12.L
Official Full Name: C-X-C motif chemokine ligand 12 L homeolog
Primary source: Xenbase:XB-GENE-6077780
Locus tag: XELAEV_18035159mg
See related: EnsemblRapid:ENSXLAG00005025245 AllianceGenome:Xenbase:XB-GENE-6077780
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: sdf1; sdf-1; cxcl12; xSDF-1; xSDF-1alpha
Summary: Enables chemokine activity. Acts upstream of or within several processes, including cell chemotaxis; mesoderm migration involved in gastrulation; and positive regulation of cytosolic calcium ion concentration. Predicted to be located in extracellular space. Is expressed in ectoderm. Human ortholog(s) of this gene implicated in breast carcinoma; diabetic angiopathy; human immunodeficiency virus infectious disease; and type 1 diabetes mellitus. Orthologous to human CXCL12 (C-X-C motif chemokine ligand 12). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

Location:: chromosome: 7L

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	7L	NC_054383.1 (65757992..65804625, complement)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	7L	NC_030736.1 (57299184..57345812, complement)

Chromosome 7L - NC_054383.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These findings support the conservation of sdf-1alpha signaling in vertebrate somite morphogenesis; however, the precise mechanism by which this signaling pathway influences somite morphogenesis is different between the fish and the frog.
Title: The Role of Sdf-1α signaling in Xenopus laevis somite morphogenesis.
expression patterns of xSDF-1a, xCXCR4, and xCXCR7 during gastrulation; results suggest SDF-1 signaling supports migration of the mesendoderm cell cohort toward the animal pole and that activin/nodal signaling acts as a regulator of the expression of xSDF-1a and xCXCR4, but not xCXCR7
Title: Expression of xSDF-1α, xCXCR4, and xCXCR7 during gastrulation in Xenopus laevis.
SDF-1/CXCR4 chemokine signaling is involved in the migration and survival or in the differentiation of PGCs in Xenopus
Title: Analysis of SDF-1/CXCR4 signaling in primordial germ cell migration and survival or differentiation in Xenopus laevis.
A significant increase of stromal cell-derived factor-1alpha and CXCR4 was observed in protein extracts of idiopathic inflammatory myopathies in comparison with normal controls.
Title: Localization of the alpha-chemokine SDF-1 and its receptor CXCR4 in idiopathic inflammatory myopathies.
SDF-1 signaling is necessary for migrations of massive numbers of cells during gastrulation.
Title: SDF-1 alpha regulates mesendodermal cell migration during frog gastrulation.

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General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables chemokine activity	IDA Inferred from Direct Assay more info	PubMed
enables chemokine activity	IEA Inferred from Electronic Annotation more info
enables cytokine activity	IEA Inferred from Electronic Annotation more info
enables growth factor activity	IEA Inferred from Electronic Annotation more info
enables integrin binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cell chemotaxis	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within chemotaxis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within defense response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within gastrulation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within immune response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within integrin activation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within mesoderm migration involved in gastrulation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of cytosolic calcium ion concentration	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular space	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: stromal cell-derived factor 1

Names: chemokine (C-X-C motif) ligand 12 (stromal cell-derived factor 1); chemokine (C-X-C motif) ligand 12 L homeolog; stromal-derived factor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001090163.1 → NP_001083632.1 stromal cell-derived factor 1 isoform beta precursor

See identical proteins and their annotated locations for NP_001083632.1

Status: PROVISIONAL

Source sequence(s)

BC061945

UniProtKB/Swiss-Prot

Q498K3, Q8UUJ9

UniProtKB/TrEMBL

A0A974H9Y3

Related

ENSXLAP00005075118.1, ENSXLAT00005076698.1

Conserved Domains (1) summary

cd00273
Location:27 → 88

Chemokine_CXC; Chemokine_CXC: 1 of 4 subgroup designations based on the arrangement of the two N-terminal cysteine residues; includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; many members ...
NM_001171778.1 → NP_001165249.1 stromal cell-derived factor 1 isoform alpha precursor

See identical proteins and their annotated locations for NP_001165249.1

Status: PROVISIONAL

Source sequence(s)

BC073527

UniProtKB/TrEMBL

A0A1L8FKT2, A0A974CFD9, A0A974H9Y3

Conserved Domains (1) summary

cd00273
Location:27 → 88

Chemokine_CXC; Chemokine_CXC: 1 of 4 subgroup designations based on the arrangement of the two N-terminal cysteine residues; includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; many members ...

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

NC_054383.1 Reference Xenopus_laevis_v10.1 Primary Assembly

Range

65757992..65804625 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_041568438.1 → XP_041424372.1 stromal cell-derived factor 1 isoform X1

UniProtKB/TrEMBL

A0A8J1L498, A0A974H9Y3

Related

ENSXLAP00005075036.1, ENSXLAT00005076616.1

Conserved Domains (1) summary

cd00273
Location:27 → 88

Chemokine_CXC; 1 of 4 subgroup designations based on the arrangement of the two N-terminal cysteine residues; includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; many members contain an RCxC motif ...