Nrt Neurotactin [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Nrtprovided by FlyBase
Official Full Name: Neurotactinprovided by FlyBase
Primary source: FLYBASE:FBgn0004108
Locus tag: Dmel_CG9704
See related: AllianceGenome:FB:FBgn0004108
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: BcDNA:LD22004; BP106; CG9704; dab; Dab; DAB; Dmel\CG9704; l(3)73Be; MabBP106; neu; Neur; nrt; NRT; Nrt BP106; NRT BP106; NT
Summary: Enables cell adhesion receptor activity. Involved in axon development; central nervous system development; and heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules. Located in axon and basolateral plasma membrane. Is expressed in several structures, including epithelial furrow; head epidermis primordium; imaginal disc; mesoderm; and visceral mesoderm derivative. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (16766072..16777465)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (16759172..16770565)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Extracellular spreading of Wingless is required for Drosophila oogenesis.
Title: Extracellular spreading of Wingless is required for Drosophila oogenesis.
In conjunction with its receptor Neurotactin (Nrt) and the effector kinase Abelson tyrosine kinase (Abl), Ama is necessary in parallel to the cell-autonomous Dfd pathway for the correct specification of the maxillary identity of NB6-4
Title: Cell-Autonomous and Non-cell-autonomous Function of Hox Genes Specify Segmental Neuroblast Identity in the Gnathal Region of the Embryonic CNS in Drosophila.
amalgam, neurotactin and the Abelson tyrosine kinase interact and affect axon pathfinding
Title: Interactions between the secreted protein Amalgam, its transmembrane receptor Neurotactin and the Abelson tyrosine kinase affect axon pathfinding.

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables cell adhesion receptor activity	IDA Inferred from Direct Assay more info	PubMed
NOT enables peptidase activity	IKR Inferred from Key Residues more info

Process	Evidence Code	Pubs
involved_in axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in axonal fasciculation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in axonogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in axonogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in central nervous system development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	IPI Inferred from Physical Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in axon	IDA Inferred from Direct Assay more info	PubMed
located_in basolateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	HDA more info	PubMed
located_in plasma membrane	HDA more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

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The following sections contain reference sequences that belong to a specific genome build. Explain