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    tal1.S T-cell acute lymphocytic leukemia 1 S homeolog [ Xenopus laevis (African clawed frog) ]

    Gene ID: 398028, updated on 9-Dec-2024

    Summary

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    Official Symbol
    tal1.S
    Official Full Name
    T-cell acute lymphocytic leukemia 1 S homeolog
    Primary source
    Xenbase:XB-GENE-865312
    Locus tag
    XELAEV_18025248mg
    See related
    EnsemblRapid:ENSXLAG00005023239 AllianceGenome:Xenbase:XB-GENE-865312
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Xenopus laevis
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
    Also known as
    scl; tcl5; bHLHa17
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and protein dimerization activity. Acts upstream of or within erythrocyte differentiation. Predicted to be located in nucleus. Is expressed in cardiovascular system; ectoderm; mesoderm; nervous system; and vestibuloauditory system. Human ortholog(s) of this gene implicated in acute lymphoblastic leukemia. Orthologous to human TAL1 (TAL bHLH transcription factor 1, erythroid differentiation factor). [provided by Alliance of Genome Resources, Dec 2024]
    Annotation information
    Annotation category: partial on reference assembly
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    Genomic context

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    See tal1.S in Genome Data Viewer
    Location:
    chromosome: 4S
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 4S NC_054378.1 (73901695..73911833, complement)
    100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 4S NC_030731.1 (67684422..67694561, complement)

    Chromosome 4S - NC_054378.1Genomic Context describing neighboring genes Neighboring gene pdzk1 interacting protein 1 S homeolog Neighboring gene uncharacterized LOC108715585 Neighboring gene SCL-interrupting locus protein homolog Neighboring gene uncharacterized LOC108715586

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A BMP-4-dependent transcriptional control element in the 5' flanking region of Xenopus SCL gene. Sanada T, et al. Biochem Biophys Res Commun, 2003 Oct 31. PMID 14559237
    2. SCL specifies hematopoietic mesoderm in Xenopus embryos. Mead PE, et al. Development, 1998 Jul. PMID 9636076
    3. Primitive erythropoiesis in the Xenopus embryo: the synergistic role of LMO-2, SCL and GATA-binding proteins. Mead PE, et al. Development, 2001 Jun. PMID 11493549
    4. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by Xenbase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within erythrocyte differentiation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within hemopoiesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    T-cell acute lymphocytic leukemia protein 1
    Names
    TAL-1
    stem cell leukaemia
    stem cell leukemia protein SCL
    tal1
    xSCL

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001088277.1 → NP_001081746.1  T-cell acute lymphocytic leukemia protein 1

      See identical proteins and their annotated locations for NP_001081746.1

      Status: PROVISIONAL

      Source sequence(s)
      AF060151
      UniProtKB/Swiss-Prot
      O73823, Q6INZ1
      UniProtKB/TrEMBL
      A0A974CZH9
      Related
      ENSXLAP00005068578.1, ENSXLAT00005070112.1
      Conserved Domains (1) summary
      smart00353
      Location:268 → 320
      HLH; helix loop helix domain

    RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Xenopus_laevis_v10.1 Primary Assembly

    Genomic

    1. NC_054378.1 Reference Xenopus_laevis_v10.1 Primary Assembly

      Range
      73901695..73911833 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O73823.1 GenPept UniProtKB/Swiss-Prot:O73823

    Gene LinkOut

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