wnt8a.L Wnt family member 8A L homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: wnt8a.L
Official Full Name: Wnt family member 8A L homeolog
Primary source: Xenbase:XB-GENE-866281
Locus tag: XELAEV_18017109mg
See related: EnsemblRapid:ENSXLAG00005000395 AllianceGenome:Xenbase:XB-GENE-866281
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: wnt8; Xwnt8; wnt-8; wnt8a; xwnt-8
Summary: Enables frizzled binding activity and protease binding activity. Acts upstream of or within several processes, including axis specification; negative regulation of cardiac cell fate specification; and regulation of DNA-templated transcription. Located in collagen-containing extracellular matrix. Colocalizes with extracellular space. Is expressed in anatomical system and primary germ layer. Orthologous to human WNT8A (Wnt family member 8A). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

Location:: chromosome: 3L

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	3L	NC_054375.1 (38020522..38025941, complement)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	3L	NC_030728.1 (24516919..24522338, complement)

Chromosome 3L - NC_054375.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Dissection of N-deacetylase and N-sulfotransferase activities of NDST1 and their effects on Wnt8 distribution and signaling in Xenopus embryos.
Title: Dissection of N-deacetylase and N-sulfotransferase activities of NDST1 and their effects on Wnt8 distribution and signaling in Xenopus embryos.
BMP signaling is enhanced intracellularly by FHL3 controlling WNT-dependent spatiotemporal emergence of the neural crest.
Title: BMP signaling is enhanced intracellularly by FHL3 controlling WNT-dependent spatiotemporal emergence of the neural crest.
Data suggest that Sizzled is unlikely able to antagonize Wnt signaling; however, structure of Sizzled provides a framework for understanding full-length structure of secreted Frizzled-related proteins such as frizzled-8 and their interaction with and antagonism of Wnt proteins such as Wnt-8.
Title: The crystal structure of full-length Sizzled from Xenopus laevis yields insights into Wnt-antagonistic function of secreted Frizzled-related proteins.
Data show that Noggin4 fine-tune the Wnt8 posterior-to-anterior gradient.
Title: Noggin4 is a long-range inhibitor of Wnt8 signalling that regulates head development in Xenopus laevis.
EFHC1 domains are involved in ciliary localization, ciliogenesis, and the regulation of Wnt8a signaling
Title: Identifying domains of EFHC1 involved in ciliary localization, ciliogenesis, and the regulation of Wnt signaling.
Sulf1 inhibits the ability of Wnt8a to activate the canonical Wnt signalling pathway.
Title: Sulf1 has ligand-dependent effects on canonical and non-canonical Wnt signalling.
study presents the structure of Xenopus Wnt8 (XWnt8) in complex with the mouse Fz8-cysteine-rich domain to a resolution of 3.25 A
Title: Structural basis of Wnt recognition by Frizzled.
PIAS proteins have differential ability to regulate signals from the growth factors activin, bone morphogenetic protein 4 (BMP4), and Wnt8.
Title: Regulation of early Xenopus development by the PIAS genes.
These findings reveal an alternative in vivo mechanism of Wnt signaling that involves TCF3 phosphorylation and subsequent derepression of target genes and link this molecular event to a specific developmental process.
Title: Regulation of TCF3 by Wnt-dependent phosphorylation during vertebrate axis specification.
Xwnt8 directly initiates expression of labial Hox genes.
Title: Xwnt8 directly initiates expression of labial Hox genes.

Submit: New GeneRIF Correction See all GeneRIFs (18)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables frizzled binding	IPI Inferred from Physical Interaction more info	PubMed
enables protease binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling receptor binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within Spemann organizer formation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within Wnt signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within anterior/posterior axis specification	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within_positive_effect anterior/posterior axis specification	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within canonical Wnt signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within canonical Wnt signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within embryonic axis specification	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of head development	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within mesoderm development	IDA Inferred from Direct Assay more info	PubMed
involved_in mesoderm development	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of cardiac cell fate specification	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neural crest cell fate commitment	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of DNA-binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in collagen-containing extracellular matrix	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular region	TAS Traceable Author Statement more info
colocalizes_with extracellular space	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: protein Wnt-8

Names: Wnt-1/int-1-related; wingless-type MMTV integration site family member 8A L homeolog; wingless-type MMTV integration site family, member 8A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001088168.1 → NP_001081637.1 protein Wnt-8 precursor

Status: PROVISIONAL

Source sequence(s)

X57234

UniProtKB/Swiss-Prot

P28026

UniProtKB/TrEMBL

Q640J8

Related

ENSXLAP00005001071.1, ENSXLAT00005001104.1

Conserved Domains (1) summary

smart00097
Location:22 → 337

WNT1; found in Wnt-1

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

NC_054375.1 Reference Xenopus_laevis_v10.1 Primary Assembly

Range

38020522..38025941 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)