Sox21b Sox21b [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Sox21bprovided by FlyBase
Official Full Name: Sox21bprovided by FlyBase
Primary source: FLYBASE:FBgn0042630
Locus tag: Dmel_CG32139
See related: AllianceGenome:FB:FBgn0042630
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG13483; CG32139; CG6419; Dmel\CG32139; Sox B2-2; Sox21B; SoxB2.2; SOXB2.2
Summary: Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in neuron differentiation and positive regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in several structures, including ectoderm; embryonic hypopharynx; gut section; imaginal disc; and supraesophageal ganglion. Orthologous to several human genes including SOX21 (SRY-box transcription factor 21). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 70D2-70D2; 3-42 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (14112405..14131324, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (14105505..14124424, complement)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Sox21b underlies the rapid diversification of a novel male genital structure between Drosophila species.
Title: Sox21b underlies the rapid diversification of a novel male genital structure between Drosophila species.

Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

Dm2052 (e-PCR)
- UniSTS:21657

Dm1776 (e-PCR)
- UniSTS:76704

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in brain development	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in neuron differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

Go to the top of the page Help

Preferred Names: Sox21b

Names: CG32139-PA; CG32139-PB; CG32139-PC; Sox21b-PA; Sox21b-PB; Sox21b-PC; sox-like

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_037436.4 Reference assembly

Range

14112405..14131324 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_140438.3 → NP_648695.1 Sox21b, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_648695.1

Status: REVIEWED

UniProtKB/TrEMBL

Q95U47, Q9VUD3

Related

FBpp0075489

Conserved Domains (1) summary

cd01388
Location:247 → 318

SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
NM_001274899.1 → NP_001261828.1 Sox21b, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001261828.1

Status: REVIEWED

UniProtKB/TrEMBL

Q95U47, Q9VUD3

Conserved Domains (1) summary

cd01388
Location:247 → 318

SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
NM_001274900.1 → NP_001261829.1 Sox21b, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001261829.1

Status: REVIEWED

UniProtKB/TrEMBL

M9PCG2

Conserved Domains (1) summary

cd01388
Location:247 → 318

SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...