twist1 twist family bHLH transcription factor 1 [Xenopus tropicalis (tropical clawed frog)] - Gene

Summary

Official Symbol: twist1provided by Xenbase
Official Full Name: twist family bHLH transcription factor 1provided by Xenbase
Primary source: Xenbase:XB-GENE-479802
See related: Ensembl:ENSXETG00000025630 AllianceGenome:Xenbase:XB-GENE-479802
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus tropicalis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana
Also known as: scs; Xtwi; acs3; X-twi; bpes2; bpes3; twist; Xtwist; twist1-a; twist1-b
Summary: Predicted to enable cis-regulatory region sequence-specific DNA binding activity and protein dimerization activity. Predicted to act upstream of or within several processes, including circulatory system development; pharyngeal system development; and regulation of bone mineralization. Is expressed in ectoderm; mesoderm; and pharyngeal arch. Human ortholog(s) of this gene implicated in Sweeney-Cox syndrome; breast cancer (multiple); and synostosis (multiple). Orthologous to human TWIST1 (twist family bHLH transcription factor 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 6

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
104	current	UCB_Xtro_10.0 (GCF_000004195.4)	6	NC_030682.2 (38448621..38450980, complement)
103	previous assembly	Xenopus_tropicalis_v9.1 (GCF_000004195.3)	6	NC_030682.1 (43550970..43553329)

Chromosome 6 - NC_030682.2 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Twist is also regulated by the ubiquitin-proteasome system.
Title: The F-box protein Ppa is a common regulator of core EMT factors Twist, Snail, Slug, and Sip1.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables cis-regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within atrioventricular valve morphogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in developmental process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within dorsal/ventral pattern formation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within pharyngeal system development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of bone mineralization	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within sprouting angiogenesis	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: twist-related protein 1

Names: twist basic helix-loop-helix transcription factor 1; twist homolog 1 (acrocephalosyndactyly 3; Saethre-Chotzen syndrome); twist transcription factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.