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    CG14120 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39463, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG14120provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0036321
    Locus tag
    Dmel_CG14120
    See related
    AllianceGenome:FB:FBgn0036321
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG14120
    Summary
    Predicted to enable RNA endonuclease activity and single-stranded DNA endodeoxyribonuclease activity. Predicted to be involved in apoptotic DNA fragmentation. Predicted to be active in mitochondrial inner membrane and nucleus. Orthologous to human EXOG (exo/endonuclease G). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG14120 in Genome Data Viewer
    Location:
    69E8-69E8; 3-39 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (12885039..12889244)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (12878139..12882344)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Equilibrative nucleoside transporter 3 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45748 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. MAAMD: a workflow to standardize meta-analyses and comparison of affymetrix microarray data. Gan Z, et al. BMC Bioinformatics, 2014 Mar 12. PMID 24621103, Free PMC Article
    2. An antiviral role for antimicrobial peptides during the arthropod response to alphavirus replication. Huang Z, et al. J Virol, 2013 Apr. PMID 23365449, Free PMC Article
    3. First transcriptome profiling of D. melanogaster after development in a deep underground low radiation background laboratory. Zarubin M, et al. PLoS One, 2021. PMID 34351964, Free PMC Article
    4. Selection for long and short sleep duration in Drosophila melanogaster reveals the complex genetic network underlying natural variation in sleep. Harbison ST, et al. PLoS Genet, 2017 Dec. PMID 29240764, Free PMC Article
    5. Drosophila microbiota modulates host metabolic gene expression via IMD/NF-κB signaling. Erkosar B, et al. PLoS One, 2014. PMID 24733183, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA endonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables single-stranded DNA endodeoxyribonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in apoptotic DNA fragmentation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrial inner membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG14120-PA
    NP_648610.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      12885039..12889244
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_140353.3 → NP_648610.1  uncharacterized protein Dmel_CG14120 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648610.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VU22
      Related
      FBpp0075602
      Conserved Domains (2) summary
      cd00091
      Location:164 → 416
      NUC; DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers.
      cl00089
      Location:718 → 967
      NUC; DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VU22 Q9VU22

    Gene LinkOut

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