ap2m1b adaptor related protein complex 2 subunit mu 1b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: ap2m1bprovided by ZNC
Official Full Name: adaptor related protein complex 2 subunit mu 1bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-1103
See related: Ensembl:ENSDARG00000033899 AllianceGenome:ZFIN:ZDB-GENE-040426-1103
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: ap2m1; zgc:56643
Summary: Predicted to enable clathrin adaptor activity. Acts upstream of or within Wnt signaling pathway. Predicted to be located in clathrin-coated pit and plasma membrane. Predicted to be part of AP-2 adaptor complex. Predicted to be active in cytoplasmic vesicle. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder. Orthologous to human AP2M1 (adaptor related protein complex 2 subunit mu 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 18

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	18	NC_007129.7 (45955005..45984585)
105	previous assembly	GRCz10 (GCF_000002035.5)	18	NC_007129.6 (45956972..45986567)

Chromosome 18 - NC_007129.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

fa30d09.s1 (e-PCR)
- UniSTS:202510

fb76e08.y1 (e-PCR)
- UniSTS:191303

G48010 (e-PCR)
- UniSTS:108775

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables clathrin adaptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables lipid binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within Wnt signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in clathrin-dependent endocytosis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within endocytosis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within intracellular protein transport	IEA Inferred from Electronic Annotation more info
involved_in intracellular protein transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within vesicle-mediated transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of AP-2 adaptor complex	IBA Inferred from Biological aspect of Ancestor more info
part_of clathrin adaptor complex	IEA Inferred from Electronic Annotation more info
located_in clathrin-coated pit	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasmic vesicle	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: AP-2 complex subunit mu-B

Names: AP-2 complex subunit mu-1-B; AP-2 mu-2 chain B; AP-2 mu-B chain; adaptor-related protein complex 2, mu 1 subunit, b; clathrin assembly protein complex 2 medium chain B; clathrin assembly protein complex 2 mu-B medium chain; clathrin coat assembly protein AP50-B; clathrin coat-associated protein AP50-B; mu2-adaptin-B; plasma membrane adaptor AP-2 50 kDa protein B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_201026.2 → NP_957320.1 AP-2 complex subunit mu-B

See identical proteins and their annotated locations for NP_957320.1

Status: PROVISIONAL

Source sequence(s)

BC049515

UniProtKB/Swiss-Prot

Q7ZW98

UniProtKB/TrEMBL

A0A8M2B673, F1RD00

Related

ENSDARP00000126276.1, ENSDART00000151418.3

Conserved Domains (1) summary

cd09251
Location:168 → 435

AP-2_Mu2_Cterm; C-terminal domain of medium Mu2 subunit in ubiquitously expressed clathrin-associated adaptor protein (AP) complex AP-2