gar1 GAR1 homolog, ribonucleoprotein [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: gar1provided by ZNC
Official Full Name: GAR1 homolog, ribonucleoproteinprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-893
See related: Ensembl:ENSDARG00000076526 AllianceGenome:ZFIN:ZDB-GENE-040426-893
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: nola1; zgc:56086
Summary: Predicted to enable box H/ACA snoRNA binding activity. Acts upstream of or within definitive hemopoiesis and rRNA processing. Predicted to be located in nucleolus. Predicted to be part of box H/ACA snoRNP complex and telomerase holoenzyme complex. Orthologous to human GAR1 (GAR1 ribonucleoprotein). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 14

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	14	NC_007125.7 (43605057..43616572, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	14	NC_007125.6 (43193384..43204899, complement)

Chromosome 14 - NC_007125.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Deficiency in dkc1 and nola1 in the H/ACA RNP complex likely contributes to the hematopoietic phenotype through p53 activation associated with rRNA processing defects during the initial stage of Dyskeratosis congenita pathogenesis.
Title: Zebrafish models for dyskeratosis congenita reveal critical roles of p53 activation contributing to hematopoietic defects through RNA processing.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables box H/ACA snoRNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within definitive hemopoiesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within definitive hemopoiesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within pseudouridine synthesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within rRNA processing	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within rRNA processing	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within ribosome biogenesis	IEA Inferred from Electronic Annotation more info
involved_in snoRNA guided rRNA pseudouridine synthesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in telomere maintenance via telomerase	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of box H/ACA snoRNP complex	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of ribonucleoprotein complex	IEA Inferred from Electronic Annotation more info
part_of telomerase holoenzyme complex	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: H/ACA ribonucleoprotein complex subunit 1

Names: GAR1 ribonucleoprotein homolog; nucleolar protein family A member 1; nucleolar protein family A, member 1 (H/ACA small nucleolar RNPs); snoRNP protein GAR1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_200975.2 → NP_957269.2 H/ACA ribonucleoprotein complex subunit 1

Status: VALIDATED

Source sequence(s)

CU467639, EH495404, EH520414

UniProtKB/TrEMBL

A0A8M1PDT4, F1RAE2

Related

ENSDARP00000101401.1, ENSDART00000111189.5

Conserved Domains (1) summary

pfam04410
Location:56 → 161

Gar1; Gar1/Naf1 RNA binding region